IMPDH2
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Official Full Name
IMP (inosine 5-monophosphate) dehydrogenase 2 -
Overview
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5-monophosphate into xanthine-5-monophosphate, which is then converted into guanosine-5-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. -
Synonyms
IMPDH2;IMP (inosine 5-monophosphate) dehydrogenase 2;inosine-5-monophosphate dehydrogenase 2;EC 1.1.1.205;IMDH2_HUMAN;IMP (inosine monophosphate) dehydrogenase 2;IMP dehydrogenase 2;IMP oxireductase 2;IMPD 2;IMPD2;IMPDH 2;IMPDH II;IMPDH-II;IMPDHII;Inosine 5 monophosphate dehydrogenase 2;inosine 5 phosphate dehydrogenase 2;inosine monophosphate dehydrogenase type II
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Insect Cells
- Mammalian Cells
- E.coli
- Human
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- Flag
- GST
- His&Fc&Avi
Involved Pathway
IMPDH2 involved in several pathways and played different roles in them. We selected most pathways IMPDH2 participated on our site, such as Purine metabolism,Drug metabolism - other enzymes,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Drug metabolism - other enzymes | GMPS,Ces2e,CES2,NAT2,UGT2A3,HPRT1,UPP2,TK2,CES1D,UGT1A2 |
| Purine metabolism | TWISTNB,PGM1,XDH,GMPR,NT5C1B-RDH14,PFAS,POLD1,PDE2A,POLR2J,DCK |
| Metabolic pathways | INPP4A,LDHB,ADSSL1,URAH,UQCRC2B,ACAT2,ARG2,TAT,PDXK,ATP6V1E1B |
Protein Function
IMPDH2 has several biochemical functions, for example, DNA binding,IMP dehydrogenase activity,RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPDH2 itself. We selected most functions IMPDH2 had, and list some proteins which have the same functions with IMPDH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| IMP dehydrogenase activity | IMPDH1,IMPDH1A,IMPDH1B |
| protein binding | FAM125A,SRGAP3,NISCH,TBC1D23,SPRR1A,C10orf62,TSEN54,ASGR2,DOK1,AHI1 |
| RNA binding | IMPDH1,SUZ12,RPL31,DIMT1,EWSR1,RBM39A,MSI1,ZBP1,CTIF,KHDRBS1B |
| nucleotide binding | MAPKAPK2A,CLK2B,PTBP1,ABCA4,ARF3B,RAB11BA,RBM24B,MAT2AB,KIAA0430,STK25A |
| DNA binding | HES7,Arid4b,SMC1B,NKX2.5,WRN,TOP3A,KLF7,POLR2F,HOXC8A,HIST1H4K |
| metal ion binding | ZNF547,RC3H2,PDE10A,KCNIP1B,WBP4,ZNF292B,BHLHE22,GTF3AA,UBE3A,ZFP131 |
Interacting Protein
IMPDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPDH2.
APIP;RSG1;BCAR3;HLA-C;VHL;EIF6;ARF6;IKBKE;TNFRSF10D;FTSJ1;TNIK;PIAS4;UBQLN4;15-deoxy-delta(12,14;ssrna_ag
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References
- Keppeke, GD; Andrade, LEC; et al. Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures. CELL AND BIOSCIENCE 5:-(2015).
- Keppeke, GD; Satoh, M; et al. Temporal evolution of human autoantibody response to cytoplasmic rods and rings structure during anti-HCV therapy with ribavirin and interferon-alpha. IMMUNOLOGIC RESEARCH 60:38-49(2014).
