Recombinant Human IMPDH2, His-tagged
Cat.No. : | IMPDH2-28270TH |
Product Overview : | Recombinant full length Human IMPDH2 with N-terminal His tag. 534 amino acids with a MWt 58kDa including tag. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | 514 amino acids |
Description : | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5-monophosphate into xanthine-5-monophosphate, which is then converted into guanosine-5-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. |
Conjugation : | HIS |
Molecular Weight : | 58.000kDa inclusive of tags |
Tissue specificity : | IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor. |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | pH: 8.00Constituents:0.32% Tris HCl, 0.03% DTT, 20% Glycerol, 0.88% Sodium chloride |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHHSSGLVPRGSHMADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF |
Sequence Similarities : | Belongs to the IMPDH/GMPR family.Contains 2 CBS domains. |
Gene Name | IMPDH2 IMP (inosine 5-monophosphate) dehydrogenase 2 [ Homo sapiens ] |
Official Symbol | IMPDH2 |
Synonyms | IMPDH2; IMP (inosine 5-monophosphate) dehydrogenase 2; inosine-5-monophosphate dehydrogenase 2; |
Gene ID | 3615 |
mRNA Refseq | NM_000884 |
Protein Refseq | NP_000875 |
Uniprot ID | P12268 |
Chromosome Location | 3p21.2 |
Pathway | Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; |
Function | DNA binding; IMP dehydrogenase activity; RNA binding; metal ion binding; nucleotide binding; |
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Not For Human Consumption!
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