Recombinant Human Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4, GST-tagged

• Cat.No.: EIF2AK4-1011H
• Product Overview: Recombinant human EIF2AK4 (192-1024) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 192-1024 a.a.
• Description: EIF2AK4 or eukaryotic translation initiation factor 2 alpha kinase 4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses. The EIF2AK4 eIF2-alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 132 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
• Specific Activity: 14 nmol/min/mg
• Purity: > 95 %
• Concentration: 0.1 ug/ul
• Sequences: 192-1024
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Hepatitis C; Herpes simplex infection; Influenza A; Measles; Protein processing in endoplasmic reticulum

Gene Information

• Gene Name: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 [ Homo sapiens ]
• Official Symbol: EIF2AK4
• Synonyms: EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4; GCN2; KIAA1338; eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein; GCN2 eIF2alpha kinase; NP_001013725.2; EC 2.7.11.1
• Gene ID: 440275
• mRNA Refseq: NM_001013703
• Protein Refseq: NP_001013725
• MIM: 609280
• UniProt ID: Q9P2K8
• Chromosome Location: 15q15.1
• Function: ATP binding; aminoacyl-tRNA ligase activity; nucleotide binding; protein homodimerization activity; protein serine/threonine kinase activity