Recombinant Human ESM1, His-tagged

• Cat.No.: ESM1-7082H
• Product Overview: Recombinant human ESM1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 20-184aa
• Description: Endothelial cell-specific molecule 1, also known as ESM1, is a proteoglycan secreted by endothelial cells and its mRNA expression is regulated by inflammatory cytokines. ESM1 expression has also been detected in different epithelia and in adipocytes. The expression of endocan is upregulated by TNF alpha, IL1 beta, or lipopolysaccharide and downregulated by IFN gamma. Genetically engineered cells overexpressing endocan has been shown to induce tumor formation, suggesting that ESM1 may be involved in the pathophysiology of tumor growth in vivo.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2M Urea,10% glycerol
• Molecular Mass: 20.5 kDa (188aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSWSNNYAV DCPQHCDSSE CKSSPRCKRT VLDDCGCCRV CAAGRGETCY RTVSGMDGMK CGPGLRCQPSNGEDPFGEEF GICKDCPYGT FGMDCRETCN CQSGICDRGT GKCLKFPFFQ YSVTKSSNRF VSLTEHDMAS GDGNIVREEV VKENAAGSPV MRKWLNPR
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: ESM1 endothelial cell-specific molecule 1 [ Homo sapiens ]
• Official Symbol: ESM1
• Synonyms: ESM1; endothelial cell-specific molecule 1; ESM-1; endocan
• Gene ID: 11082
• mRNA Refseq: NM_001135604
• Protein Refseq: NP_001129076
• MIM: 601521
• UniProt ID: Q9NQ30
• Chromosome Location: 5q11
• Function: growth factor activity; insulin-like growth factor binding