ESM1
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Official Full Name
endothelial cell-specific molecule 1 -
Overview
Endothelial cell-specific molecule 1 is a protein that in humans is encoded by the ESM1 gene. This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. The ESM-1 gene product is also called endocan since 2001, when it was characterized as a dermatan sulfate proteoglycan by Bechard et al. Recently, endocan/ESM-1 has been described as a specific biomarker of tip cells during neoangiogenesis by independent teams. Endocan expression has been shown to be increase in presence of pro-angiogenic growth factors such as VEGF (vascular endothelial growth factor) or FGF-2 (fibroblast growth factor 2). In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against endocan/ESM-1. -
Synonyms
ESM1;endocan;endothelial cell-specific molecule 1
Recombinant Proteins
- Mouse
- Human
- Rat
- Zebrafish
- Mammalian cells
- Insect Cell
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- Insect Cells
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- His&Fc&Avi
- His&SUMO
- His&MBP
- His&GST
Involved Pathway
ESM1 involved in several pathways and played different roles in them. We selected most pathways ESM1 participated on our site, such as Gastric cancer network 1, which may be useful for your reference. Also, other proteins which involved in the same pathway with ESM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gastric cancer network 1 | ACTL6A,LIN9,SMOC2,C21orf33,TPX2,GATS,S100P,MYBL2,RNF216,ECT2 |
Protein Function
ESM1 has several biochemical functions, for example, hepatocyte growth factor receptor binding,insulin-like growth factor binding,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ESM1 itself. We selected most functions ESM1 had, and list some proteins which have the same functions with ESM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hepatocyte growth factor receptor binding | GLMN |
| integrin binding | PTPN2,ADAM9,MMP14,SRC,THBS1,SFRP2,S1PR3,PPAP2B,CD226,TNN |
| insulin-like growth factor binding | IGFBP5B,IGFBP2B,IGF1RB,HTRA1,CYR61L1,IGFBP1A,IGFBP6A,WISP1B,WISP2,IGFBP6B |
Interacting Protein
ESM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ESM1.
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