Recombinant Human DOCK8 protein, MYC/DDK-tagged

• Cat.No.: DOCK8-12H
• Product Overview: Recombinant Human DOCK8 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 238.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: DOCK8 dedicator of cytokinesis 8 [ Homo sapiens ]
• Official Symbol: DOCK8
• Synonyms: 1200017A24Rik; epididymis luminal protein 205
• Gene ID: 81704
• mRNA Refseq: NM_203447
• Protein Refseq: NP_982272
• MIM: 611432
• UniProt ID: Q8NF50
• Chromosome Location: 9p24.3
• Pathway: Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem
• Function: guanyl-nucleotide exchange factor activity