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Dock8

Official Full Name

dedicator of cytokinesis 8

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Yeast

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DOCK8-12H	Recombinant Human DOCK8 protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	DOCK8-3734H	Recombinant Human DOCK8 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	DOCK8-2255H	Recombinant Human DOCK8 Protein (560-729 aa), His-tagged	Yeast	His	560-729 aa	Inquiry
Mouse	DOCK8-4758M	Recombinant Mouse DOCK8 Protein	Mammalian Cell	His		Inquiry
Mouse	DOCK8-2251M	Recombinant Mouse DOCK8 Protein (561-730 aa), His-tagged	Yeast	His	561-730 aa	Inquiry
Mouse	Dock8-2628M	Recombinant Mouse Dock8 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Mouse	DOCK8-2481M	Recombinant Mouse DOCK8 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	DOCK8-2418M	Recombinant Mouse DOCK8 Protein (561-730 aa), His-tagged	E.coli	His	561-730 aa	Inquiry
Mouse	DOCK8-2481M-B	Recombinant Mouse DOCK8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Dock8-4614M	Recombinant Mouse Dock8 protein, His-tagged	E.coli	His	1633-2067aa	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

Dock8 involved in several pathways and played different roles in them. We selected most pathways Dock8 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Hemostasis, cyclic AMP biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Dock8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Factors involved in megakaryocyte development and platelet production	KIF26A;KDM1A;DOCK9;NFE2;GATA5;DOCK7;HBE1;HBB-Y;H3F3D
Hemostasis	GATA6;CFHL2;BRPF3;GRB14;EHD1;LOC100514666;AMICA1;SLC7A10;GRB7
cyclic AMP biosynthesis	ARHGAP33;DOCK8;RALGAPA1;PDC;RIC8;RAP1GAP2;GARNL3

Dock8 has several biochemical functions, for example, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Dock8 itself. We selected most functions Dock8 had, and list some proteins which have the same functions with Dock8. You can find most of the proteins on our site.

Function	Related Protein
guanyl-nucleotide exchange factor activity	RIC8B;SERGEF;ARFGEF1;ARHGEF1B;ARHGEF7;DENND1C;VAV3;SPATA13;DENND6A

Dock8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Dock8 here. Most of them are supplied by our site. Hope this information will be useful for your research of Dock8.

Research Area

Burbage, M; Keppler, SJ; et al. Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity. JOURNAL OF EXPERIMENTAL MEDICINE 212:53-72(2015).

Janssen, E; Morbach, H; et al. Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 134:1365-1374(2014).