Recombinant Human dishevelled segment polarity protein 2 Protein, Strep&Flag tagged

• Cat.No.: DVL2-173H
• Product Overview: Recombinant human DVL2 protein (O14641) (Asp 598-Gln 697) with both Twin Strep, Flag tag at the C-terminus was expressed E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Flag&Strep
• Protein Length: 598-697aa
• Description: This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
• Tag: C-Strep&Flag
• Molecular Mass: 14.9 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: DVL2 dishevelled segment polarity protein 2 [ Homo sapiens (human) ]
• Official Symbol: DVL2
• Synonyms: DVL2; dishevelled, dsh homolog 2 (Drosophila); dishevelled 2 (homologous to Drosophila dsh); segment polarity protein dishevelled homolog DVL-2; DSH homolog 2; dishevelled-2
• Gene ID: 1856
• mRNA Refseq: NM_004422
• Protein Refseq: NP_004413
• MIM: 602151
• UniProt ID: O14641