DVL2
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Official Full Name
dishevelled, dsh homolog 2 -
Overview
Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3beta promoting beta-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK. Th -
Synonyms
DVL2;dishevelled, dsh homolog 2 (Drosophila);dishevelled 2 (homologous to Drosophila dsh);segment polarity protein dishevelled homolog DVL-2;DSH homolog 2;dishevelled-2
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- Wheat Germ
- E.coli
- Mammalian Cell
- HEK293
- E. coli
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- C-Strep&Flag
Involved Pathway
DVL2 involved in several pathways and played different roles in them. We selected most pathways DVL2 participated on our site, such as Asymmetric localization of PCP proteins,Basal cell carcinoma,Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DVL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basal cell carcinoma | SETD6,WNT16,GLI1,AXIN1,WNT2,WNT5A,FZD8,SUFU,SMO,WNT6 |
| Beta-catenin independent WNT signaling | AP2M1,CTNNB2,AP2B1,CLTC,PRICKLE1,ITPR2,GNB5,ROR2,PRICKLE1B,MOV10 |
| DNA damage response (only ATM dependent) | DVL3,MLKL,DVL1,BIK |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | DVL1,DVL3,WNT8-2,CSNK1G2 |
| Canonical Wnt signaling pathway | CSNK1D,DVL3,KLHL12,DVL1,CSNK1A1,CSNK1E |
| HTLV-I infection | PIK3R3,TSPO,XBP1,ANAPC5,WNT10B,CCND3,TNF,PIK3CD,IKBKB,TGFB1 |
| Asymmetric localization of PCP proteins | PRICKLE1,PRICKLE1B |
| Degradation of DVL | DVL1,DACT1,HECW1,DVL3,KLHL12,HECW1B |
Protein Function
DVL2 has several biochemical functions, for example, frizzled binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DVL2 itself. We selected most functions DVL2 had, and list some proteins which have the same functions with DVL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PKN3,FAM131B,PTH1R,RAP2A,SREK1,KCNJ10,CREBZF,DTNB,KCTD9,TMSB4Y |
| protein self-association | RSAD2,TTN,EPB49,PABPN1,TNFAIP3,CNTN2,NKX3-1,ZFP639,TRIM32,ZNF496 |
| identical protein binding | RYR2,FXR2,VWF,MRFAP1L1,ASS1,RCAN1,VIM,RPE,ZHX2,MYBPC3 |
| frizzled binding | WNT16,WNT8B,WNT9A,WNT2BA,WNT3,BAMBI,SDCBP,WNT7AA,DVL3,CTHRC1 |
| protein domain specific binding | HIST1H4I,STRN4,CSNK2B,ST13,ZNF521,KCNN2,IKBKG,IL1B,NR0B2,SHC4 |
Interacting Protein
DVL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DVL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DVL2.
DACT1;Smurf2;Pard6a
DVL2 Related Signal Pathway
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References
- Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).
- Ye, ZD; Zhang, CX; et al. Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. NATURE COMMUNICATIONS 4:-(2013).
