Recombinant Human COL1A1, GST-tagged

• Cat.No.: COL1A1-113H
• Product Overview: Human COL1A1 partial ORF ( NP_000079.1, 1021 a.a. - 1108 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: GST
• Description: This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
• Molecular Mass: 35.42 kDa
• AA Sequence: EGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGD KGETGEQGDRGIK
• Applications: ELISA; WB-Re; AP; Array
• Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: COL1A1?collagen, type I, alpha 1 [?Homo sapiens?(human) ]
• Official Symbol: COL1A1
• Synonyms: COL1A1; OI4; collagen, type I, alpha 1; collagen alpha-1(I) chain; alpha-1 type I collagen; pro-alpha-1 collagen type 1; collagen alpha 1 chain type I; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain
• Gene ID: 1277
• mRNA Refseq: NM_000088
• Protein Refseq: NP_000079
• MIM: 120150
• UniProt ID: P02452
• Chromosome Location: 17q21.33
• Pathway: Binding and Uptake of Ligands by Scavenger Receptors; ECM-receptor interaction; Focal Adhesion
• Function: extracellular matrix structural constituent; identical protein binding; metal ion binding