Recombinant Human CHMP2B Protein, MYC/DDK-tagged

• Cat.No.: CHMP2B-3235H
• Product Overview: Recombinant Human CHMP2B protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 23.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: CHMP2B charged multivesicular body protein 2B [ Homo sapiens ]
• Official Symbol: CHMP2B
• Synonyms: ALS17; CHMP2.5; DMT1; VPS2-2; VPS2B
• Gene ID: 25978
• mRNA Refseq: NM_001244644
• Protein Refseq: NP_001231573
• UniProt ID: Q9UQN3