Recombinant Full Length Human cytokine receptor like factor 3 Protein, His&Flag&StrepII tagged

• Cat.No.: CRLF3-136H
• Product Overview: Recombinant human CRLF3 protein (Q8IUI8) (Met 1-Phe 442) with a Twin strep tag at the N-terminus and both His, Flag tag at the C-terminus was expressed in E. coli.

Specification

• Description: This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK).
• Tag: N-Twin strep and C-His&Flag
• Protein length: 1-442aa
• Molecular Mass: 56.4 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: CRLF3 cytokine receptor like factor 3 [ Homo sapiens (human) ]
• Official Symbol: CRLF3
• Synonyms: CRLF3; cytokine receptor-like factor 3; CREME9; CYTOR4; cytokine receptor-like molecule 9; cytokine receptor related protein 4; cytokine receptor-related protein 4; type I cytokine receptor like factor; type I cytokine receptor-like factor p48; FRWS; p48.2; CREME-9; MGC20661
• Gene ID: 51379
• mRNA Refseq: NM_015986
• Protein Refseq: NP_057070
• MIM: 614853
• UniProt ID: Q8IUI8