Native Human GC-Globulin

• Cat.No.: GC-198H

Specification

• Species: Human
• Source: Human Plasma
• Tag: Non
• Description: An alpha 2 glycoprotein composed of a single polypeptide chain and present in plasma at levels of 20-55 mg/100 ml. It functions in the binding and transport of vitamin D and may also play an important role in actin homeostatis since it has been shown to bind monomeric actin with high affinity. GC-globulin also binds membranes of both circulating B and T lymphocytes. Clinically, concentrations are reduced in patients with severe liver diseases. GC-globulin may also play an important role in the mechanism of the osteomalacia that occurs with Itai-Itai disease.
• Form: Lyophilized
• Molecular Mass: 56, 000
• Purity: >= 95% by SDS-PAGE
• Usage: For research use or for use in further manufacturing.
• Quality Control Test: Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
• Stability: >1 year
• Storage: <=>
• Storage Buffer: 20 mM NaH2PO4, 0.15 M NaCl pH 7.4

Gene Information

• Gene Name: GC group-specific component (vitamin D binding protein) [ Homo sapiens ]
• Official Symbol: GC
• Synonyms: GC; group-specific component (vitamin D binding protein); vitamin D-binding protein; DBP; hDBP; VDBP; VDB; gc-globulin; vitamin D-binding alpha-globulin; GRD3; VDBG; DBP/GC
• Gene ID: 2638
• mRNA Refseq: NM_000583
• Protein Refseq: NP_000574
• UniProt ID: P02774
• Chromosome Location: 4q12-q13
• Pathway: Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Metabolism of steroid hormones and vitamins A and D, organism-specific biosystem; Vitamin D (calciferol) metabolism, organism-specific biosystem
• Function: actin binding; vitamin D binding; vitamin transporter activity