Native Human GC protein

• Cat.No.: GC-524H
• Product Overview: Native Human GC Globulin(Vitamin D Binding Protein) was purified from Human Plasma.

Specification

• Species: Human
• Source: Human Plasma
• Tag: Non
• Description: An alpha 2 glycoprotein composed of a single polypeptide chain and present in plasma at levels of 20-55 mg/100 ml. It functions in the binding and transport of vitamin D and may also play an important role in actin homeostatis since it has been shown to bind monomeric actin with high affinity. GC-globulin also binds membranes of both circulating B and T lymphocytes. Clinically, concentrations are reduced in patients with severe liver diseases. GC-globulin may also play an important role in the mechanism of the osteomalacia that occurs with Itai-Itai disease.
• Form: Lyophilized from 20 mM Na phosphate, pH 7.4, with 150 mM NaCl.
• Molecular Mass: 56000
• Purity: >=95% by SDS-PAGE

Gene Information

• Gene Name: GC group-specific component (vitamin D binding protein) [ Homo sapiens ]
• Official Symbol: GC
• Synonyms: GC; group-specific component (vitamin D binding protein); vitamin D-binding protein; DBP; hDBP; VDBP; VDB; gc-globulin; vitamin D-binding alpha-globulin; GRD3; VDBG; DBP/GC
• Gene ID: 2638
• mRNA Refseq: NM_000583
• Protein Refseq: NP_000574
• MIM: 139200
• UniProt ID: P02774
• Chromosome Location: 4q12-q13
• Pathway: Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Metabolism of steroid hormones and vitamins A and D, organism-specific biosystem; Vitamin D (calciferol) metabolism, organism-specific biosystem
• Function: actin binding; vitamin D binding; vitamin transporter activity