Native Human COL4A1 Protein

• Cat.No.: COL4A1-001H
• Product Overview: Native Human COL4A1 Protein was prepared from human placenta and was chromatographically and immunologically pure.
  This product is free from other collagens, human serum proteins and non-collagen extracellular matrix proteins. This product reacts with anti-Collagen Type IV. Reaction with anti-Collagen I, II, III, V or VI is negligible (typically less than 1% cross-reactivity was detected by ELISA).

Specification

• Description: This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.
• Source: Placenta
• Species: Human
• Applications: WB: 1:1000
  ELISA: 1:10000
  Immunohistochemistry: 1:100 - 1:500
  Immunohistochemistry-Paraffin: 1:100 - 1:500
• Storage: Store at 4 centigrade. Do not freeze.
• Concentration: 1.0 mg/mL
• Storage Buffer: 0.5 M Acetic Acid
• Preservative: 0.01% Sodium Azide

Gene Information

• Gene Name: COL4A1 collagen type IV alpha 1 chain [ Homo sapiens (human) ]
• Official Symbol: COL4A1
• Synonyms: COL4A1; collagen type IV alpha 1 chain; BSVD; BSVD1; RATOR; PADMAL; COL4A1s; collagen alpha-1(IV) chain; COL4A1 NC1 domain; arresten; collagen IV, alpha-1 polypeptide; collagen of basement membrane, alpha-1 chain
• Gene ID: 1282
• mRNA Refseq: NM_001845
• Protein Refseq: NP_001836
• MIM: 120130
• UniProt ID: P02462