Active Recombinant TMEM173 (STING) Protein, His tagged

• Cat.No.: STING-03H
• Product Overview: Recombinant TMEM173 (STING) (149-379) corresponding to amino acids 149-379 of human STING (accession number NP_938023.1) was expressed in E. coli cells and contains a C-terminal 6×His tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 149-379 aa
• Description: STING (Stimulator Of Interferon Genes, also known as TMEM173, HMITA, NET23, ERIS, MPYS, MITA, SAVI) is a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. STING is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. It has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. It acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state.
• Molecular Mass: 27.3 kDa
• Purity: ≥ 65%
• Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80 centigrade to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
• Concentration: 0.3 μg/μL

Gene Information

• Gene Name: STING1 stimulator of interferon response cGAMP interactor 1 [ Homo sapiens (human) ]
• Official Symbol: STING1
• Synonyms: STING1; stimulator of interferon response cGAMP interactor 1; ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta; stimulator of interferon genes protein; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; endoplasmic reticulum IFN stimulator; endoplasmic reticulum interferon stimulator; mitochondrial mediator of IRF3 activation; stimulator of interferon protein; stimulator of interferon response cGAMP interactor-deltaC; stimulator of interferon response cGAMP interactor-deltaN; sting 1; transmembrane protein 173
• Gene ID: 340061
• mRNA Refseq: NM_198282
• Protein Refseq: NP_938023
• MIM: 612374
• UniProt ID: Q86WV6