Active Recombinant Mouse Gfral Protein, Fc-tagged

• Cat.No.: GFRAL-6321M
• Product Overview: The extracellular domain of mouse GFRAL (aa 20-349) fused to the N-terminus of the Fc region of mouse IgG2a was expressed in HEK 293 cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Fc
• Protein Length: 20-349 a.a.
• Description: GFRAL (GDNF receptor α-like) is a distant member of the GDNFR family of proteins. Mouse GFR α-like contains a 330aa extracellular domain. It is expressed on hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance.
• Bio-activity: Measured by its binding ability in a functional ELISA.
• Endotoxin: <0.06 EU/μg purified protein.
• Purity: ≥98% (SDS-PAGE)
• Stability: Stable for at least 1 year after receipt when stored at -20 centigrade.
  Working aliquots are stable for up to 3 months when stored at -20 centigrade.
  Avoid freeze/thaw cycles.
• Storage: Short term storage at +4 centigrade, long term storage at -20 centigrade.
• Storage Buffer: Lyophilized from 0.2 μm-filtered solution in PBS.
• Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
• Shipping: BLUE ICE

Gene Information

• Gene Name: Gfral GDNF family receptor alpha like [ Mus musculus (house mouse) ]
• Official Symbol: Gfral
• Synonyms: Gfral; GDNF family receptor alpha like; Gral; AY457637; GDNF family receptor alpha-like; GDNF receptor alpha-like
• Gene ID: 404194
• mRNA Refseq: NM_205844
• Protein Refseq: NP_995316
• UniProt ID: Q6SJE0