Recombinant Human GFRAL protein, His-tagged

• Cat.No.: GFRAL-002H
• Product Overview: Recombinant Human GFRAL protein (Ser19-Glu351) was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: 333
• Description: Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
• Molecular Mass: The predicted molecular mass is 38 kDa, and the actual MW is about 40 kDa in SDS-PAGE under reducing conditions.
• Endotoxin: <1 EU/mg as determined by LAL test.
• Purity: ＞80%，by SDS-PAGE under reducing conditions.

Gene Information

• Gene Name: GFRAL
• Official Symbol: GFRAL
• Synonyms: GRAL; UNQ9356; C6orf144; bA360D14.1
• Gene ID: 389400
• mRNA Refseq: NM_207410.2
• Protein Refseq: NP_997293.2
• MIM: 617837
• UniProt ID: Q6UXV0