Recombinant Human GFRAL protein, His-Avi-tagged

• Cat.No.: GFRAL-60H
• Product Overview: Human LILRA3 Protein is expressed from mammalian with His and Avi Tag at the C-terminal. It contains Gly24-Glu439.

Specification

• Species: Human
• Source: HEK293
• Tag: Avi&His
• Protein Length: Gly24-Glu439
• Description: GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain. GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.
• Form: Supplied as 0. 22um filtered solution in 20mM PB, 300mM NaCl (pH 6. 5).
• Molecular Mass: The protein has a predicted MW of 40. 7 kDa. Due to glycosylation, the protein migrates to 48-62KDa based on Bis-Tris PAGE result.
• Endotoxin: Less than 0. 1EU per ug by the LAL method.
• Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: GFRAL GDNF family receptor alpha like [ Homo sapiens ]
• Official Symbol: GFRAL
• Synonyms: GFR alpha like; GFR alpha-like; GFRAL; GRAL; GDNF family receptor alpha-lik; C6orf144
• Gene ID: 389400
• mRNA Refseq: NM_207410. 2
• Protein Refseq: NP_997293. 2
• MIM: 617837
• UniProt ID: Q6UXV0