Active Recombinant Human F9 Protein, His-tagged

Cat.No. : F9-013H
Product Overview : Active recombinant human C-terminal His-tagged coagulation factor IX (29-461) was expressed in HEK293 cells.
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Species : Human
Source : HEK293
Tag : His
Protein Length : 29-461
Description : This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
Form : Lyophilized
Bio-activity : Measured by its ability to cleave the peptide substrate Z-D-Arg-Gly-Arg-pNA. The specific acitivity is > 20 pmols/min/ μg.
Molecular Mass : 50 kDa
Endotoxin : <1.0 EU/ μg, determined by the LAL endotoxin assay.
Purity : ≥95% as determined by SDS-PAGE
Stability : ≥ 2 years
Storage : At -80 centigrade.
Storage Buffer : Sterile PBS, pH 7.4
Gene Name F9 coagulation factor IX [ Homo sapiens (human) ]
Official Symbol F9
Synonyms F9; coagulation factor IX; FIX; P19; PTC; HEMB; THPH8; F9 p22; coagulation factor IX; Christmas factor; factor 9; factor IX F9; plasma thromboplastic component; plasma thromboplastin component; EC 3.4.21.22
Gene ID 2158
mRNA Refseq NM_000133
Protein Refseq NP_000124
MIM 300746
UniProt ID P00740

Not For Human Consumption!

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