Native Human F9

• Cat.No.: F9-26523TH
• Product Overview: Full length native Human Factor IXa purified from Human plasma, with the active site labeled by incubation with Fluorescein-Phe-Phe-Arg-CMK, MWt 45kDa.

Specification

• Species: Human
• Tag: Non
• Description: This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 0.1M Sodium chloride, 0.1M HEPES, 1mM EDTA, pH 7.4
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Full Length: Full L.

Gene Information

• Gene Name: F9 coagulation factor IX [ Homo sapiens ]
• Official Symbol: F9
• Synonyms: F9; coagulation factor IX; Christmas disease; Factor IX; FIX; hemophilia B; plasma thromboplastic component
• Gene ID: 2158
• mRNA Refseq: NM_000133
• Protein Refseq: NP_000124
• Uniprot ID: P00740
• Chromosome Location: Xq26.3-q27.1
• Pathway: Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Extrinsic Pathway, organism-specific biosystem
• Function: calcium ion binding; peptidase activity; serine-type endopeptidase activity