SHH
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Official Full Name
sonic hedgehog -
Overview
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008] -
Synonyms
SHH;sonic hedgehog;TPT;HHG1;HLP3;HPE3;SMMCI;TPTPS;MCOPCB5;sonic hedgehog protein;sonic hedgehog homolog
Recombinant Proteins
- Mouse
- Human
- Rat
- Chicken
- HEK293
- E.coli
- CHO
- CHO-K1
- Mammalian Cell
- Human Cell
- HEK293F
- E. coli. This product is produced with no animal or human origin raw products.
- HEK293T
- His
- Non
- His&T7
- N-His-SUMO
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SHH involved in several pathways and played different roles in them. We selected most pathways SHH participated on our site, such as Hedgehog signaling pathway,Pathways in cancer,Basal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basal cell carcinoma | PTCH2,BMP4,WNT6,STK36,DVL2,GLI2,WNT7B,FZD3,DVL3,SETD6 |
| Hedgehog signaling pathway | IHHA,GSK3B,HHIP,IHH,WNT6,DYRK1A,CSNK1G2,ZIC2B,PRKACBA,SHHB |
| Pathways in cancer | ROCK2,RXRA,SMAD4,HRAS,WNT7B,ITGA3,FGF9,FIGF,BCR,PIK3R3 |
Protein Function
SHH has several biochemical functions, for example, calcium ion binding,glycoprotein binding,glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHH itself. We selected most functions SHH had, and list some proteins which have the same functions with SHH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| patched binding | SETD6,CCNB1,CAV1,IHH,DHH,PTCH1,SMO,BBS1 |
| protein binding | CHEK1,VEGFAA,LCMT2,MARK4,NKAP,ZNF131,LPXN,EID3,KDM5A,ITM2B |
| glycosaminoglycan binding | SERPINE2,VCAN,BGN,HABP2,SPOCK2,VIT,TGFBR2,ENG,EPYC,TGFBR3 |
| laminin-1 binding | NTN4,SLIT2,LACRT,NID1,DAG1,UBE4A |
| calcium ion binding | LRP2,CABP5A,EFEMP2A,ITSN1,SYT10,LALBA,PLCD4,BGLAP2,MMP25,MMP15 |
| glycoprotein binding | FBXO27,PLAT,PIP,DNAJA2,TGFB1,SERPINA1A,DNAJC5,BBC3,CALR,FLNA |
| zinc ion binding | ADAM23,LIG3,MT3,BTR22,RFPL2,ADH1B,ADAM8,NR1H4,PIAS1,RNF220 |
| peptidase activity | PSMB11,lon,BAP1,KEX2,NOTS,MCPT2,TPP1,GM12824,PSMB9A,PPPDE2 |
| morphogen activity | DAND5,NODAL,CER1,NBL1,GREM1 |
Interacting Protein
SHH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHH here. Most of them are supplied by our site. Hope this information will be useful for your research of SHH.
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References
- Liu, ZQ; Xu, JD; et al. A critical role of autocrine sonic hedgehog signaling in human CD138(+) myeloma cell survival and drug resistance. BLOOD 124:2061-2071(2014).
- Choe, JY; Yun, JY; et al. Sonic hedgehog signalling proteins are frequently expressed in retinoblastoma and are associated with aggressive clinicopathological features. JOURNAL OF CLINICAL PATHOLOGY 68:6-11(2015).
