MME
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Official Full Name
membrane metallo-endopeptidase -
Overview
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5 untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008] -
Synonyms
MME;membrane metallo-endopeptidase;NEP;SFE;CD10;CALLA;neprilysin;enkephalinase;atriopeptidase;neprilysin-390;neprilysin-411;skin fibroblast elastase;neutral endopeptidase 24.11;membrane metallo-endopeptidase variant 1;membrane metallo-endopeptidase variant 2;common acute lymphocytic leukemia antigen;membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase);membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Chicken
- Rat
- Rhesus macaque
- Oryctolagus cuniculus (Rabbit)
- HEK293
- Sf21 Cells
- CHO
- Insect cells
- N-His
- Mammalian Cells
- E.coli
- Human Cells
- Wheat Germ
- Sf9 Cells
- Mouse
- Yeast
- In Vitro Cell Free System
- Fc
- Non
- His
- His&GST
- StrepII
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
MME involved in several pathways and played different roles in them. We selected most pathways MME participated on our site, such as Renin-angiotensin system,Hematopoietic cell lineage,Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with MME were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | MAPK1,CASP9,ATP5G3,MAPK3,ATP5G1,NDUFA4,CHP,CYCS,NDUFC2,COX6C |
| Renin-angiotensin system | KLK1B3,Ren1,REN,ANPEP,ATP6AP2,AGTR1A,KLK1B9,MRGPRD,KLK1B11,KLK1B5 |
| Protein digestion and absorption | COL6A6,ATP1A2,ATP1A4,SLC8A1,DPP4,ATP1A1,SLC3A1,COL18A1,KCNJ13,CTRL |
| Hematopoietic cell lineage | CD19,IL9R,CR1,CD1B,CR2,GP1BB,CSF1,ITGA4,CD59,IL4 |
Protein Function
MME has several biochemical functions, for example, endopeptidase activity,exopeptidase activity,metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MME itself. We selected most functions MME had, and list some proteins which have the same functions with MME. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | CPNE1,PSMA6,RHBDD1,KLK1B11,Ren1,ADAM10,F9,AP1S2,CD46,CTSH |
| metalloendopeptidase activity | ASTL,ADAM10A,MMP17,ADAMTS18,ADAM10B,MMP8,ADAM18,MMP13,ADAMTS13,ADAM8 |
| protein binding | 2610109H07Rik,BAG6,SYT6,RBM23,ZBTB43,TECPR1,ZNF830,PAGE2,PDPK1,POLRMT |
| peptide binding | PPYR1,GNRHR2,ERCC3,CTSL2,NUP98,IDE,RPS6KB2,CRHBP,CALR,PPIA |
| zinc ion binding | TAF3,MICALL2A,MARCH7,CPN1,MMP23BB,CUL9,ING5A,MYT1LA,ZNF257,LIMK2 |
| exopeptidase activity | ACE,GGH |
Interacting Protein
MME has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MME here. Most of them are supplied by our site. Hope this information will be useful for your research of MME.
HSPB1;HSPA1A;CD9;ACTB;NDRG1;loc653596_human_protein;FAAH;SLC9A3R1;TM9SF1;IRAK2
Resources
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References
- Chakrabarti, S; Multani, S; et al. Whole genome expression profiling in chewing-tobacco-associated oral cancers: a pilot study. MEDICAL ONCOLOGY 32:-(2015).
- Wekesa, SN; Sangula, AK; et al. Characterisation of recent foot-and-mouth disease viruses from African buffalo (Syncerus caffer) and cattle in Kenya is consistent with independent virus populations. BMC VETERINARY RESEARCH 11:-(2015).
