IGFBP3
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Official Full Name
IGFBP3 insulin-like growth factor binding protein 3 -
Overview
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an;IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor;acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the;plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate;transcriptional splice variants, encoding different isoforms, have been characterized. -
Synonyms
IGFBP3;insulin-like growth factor binding protein 3;insulin-like growth factor-binding protein 3;acid stable subunit of the 140 K IGF complex;binding protein 29;binding protein 53;BP 53;growth hormone dependent binding protein;IBP3;IGF binding protein 3;IBP-3;IGFBP-3;IGF-binding protein 3;growth hormone-dependent binding protein;BP-53
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Zebrafish
- Rhesus macaque
- Chicken
- Cattle
- Pig
- Rat
- E. coli
- HEK293
- Mammalian cells
- Mammalian Cell
- E.coli
- Human Cell
- Rabbit
- GST
- His
- Non
- His&T7
- C-His&Flag
- His&Fc&Avi
- N-His-SUMO
- His&TRxA
Involved Pathway
IGFBP3 involved in several pathways and played different roles in them. We selected most pathways IGFBP3 participated on our site, such as p signaling pathway,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p signaling pathway | RPRMA,SHISA5,BIDA,CCND2A,Casp3,IGF1,CYCS,RCHY1,RPRM,CCNB3 |
| Transcriptional misregulation in cancer | IL1R2,HHEX,LYL1,HOXA11,FLI1,PLAT,HDAC1,ELANE,MAX,CD86 |
Protein Function
IGFBP3 has several biochemical functions, for example, fibronectin binding,insulin-like growth factor I binding,insulin-like growth factor II binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP3 itself. We selected most functions IGFBP3 had, and list some proteins which have the same functions with IGFBP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KAT8,CD6,ZSCAN12,MEIS1B,ZNF193,NAPG,UHRF1,F7,BBS10,STMN2 |
| insulin-like growth factor II binding | IGFBP2A,IGFBP5A,IGFBP5B,IGFBP6B,IGFBP6,INSR,IGFBP5,IGFBP6A,IGFBP4,IGFBP1B |
| insulin-like growth factor I binding | IGFBP6,IGFBP6B,IGFBP6A,IGFBP5B,IGFBP1B,IGFBP2A,IGFBP5A,INSR,IGFBP5,IGFBP4 |
| insulin-like growth factor binding | CTGFB,IGFBP2B,IGFBP7,IGFBP5A,WISP2,ESM1,IGFBP1B,Igfbpl1,HTRA1,IGFALS |
| metal ion binding | NKD2B,ZNF45,WT1B,NCS1A,ZNRF2B,ZNF317,FYN,CA15B,KLF2,SRSF7A |
| fibronectin binding | CTSL1,CCDC80,ITGB1,CTGF,ITGB3,IGFBP5,LACRT,IGFBP5B,THBS1,IGFBP5A |
| protein tyrosine phosphatase activator activity | PPP2R4 |
Interacting Protein
IGFBP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP3.
EGFR;PRKDC;AURKA;BUB1;KRAS;CCND1;BMPR1A;GTF3C1;POLA2;STK11;q8czf9_yerpe;dinB;FBXW7;MLH3;RAD54B
Resources
Research Area
Osteoclast MarkersOsteoblast and Osteoclast Markers
Osteogenesis Markers
IGF Binding Protein & Regulator
Medulloblastoma Biomarkers
Related Services
Related Products
References
- Moody, G; Beltran, PJ; et al. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. JOURNAL OF ENDOCRINOLOGY 221:145-155(2014).
- Lariviere, N; Law, J; et al. Dissection of a Novel Autocrine Signaling Pathway via Quantitative Secretome and Interactome Mapping. JOURNAL OF PROTEOME RESEARCH 13:3432-3443(2014).
