GHR
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Official Full Name
growth hormone receptor -
Overview
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011] -
Synonyms
GHR;growth hormone receptor;GHBP;GH receptor;serum binding protein;somatotropin receptor;growth hormone binding protein
Recombinant Proteins
- Mouse
- Rat
- Rabbit
- Cynomolgus
- Chicken
- Human
- Rhesus macaque
- Bovine
- Ovine
- Pig
- Dog
- Oryctolagus cuniculus
- Bos indicus (Zebu)
- Mus musculus
- Sus scrofa (Pig)
- Macaca mulatta
- HEK293
- E.coli
- Mammalian Cells
- Mouse myeloma cell
- Insect Cells
- Human Cells
- CHO
- Wheat Germ
- His
- Fc
- Non
- SUMO
- T7
- Myc
- GST
- Avi
Involved Pathway
GHR involved in several pathways and played different roles in them. We selected most pathways GHR participated on our site, such as Cytokine-cytokine receptor interaction,Neuroactive ligand-receptor interaction,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GHR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | PPP2R5E,IFNA4,MAP2K2,PRL,Il6ra,PHLPP1,GNG12,MAP2K1,IFNA10,DDIT4 |
| Jak-STAT signaling pathway | IFNA3,IFNA6,IFNGR1,GRB2A,IL9R,Il6ra,STAT3,PTPN6,IFNG1-2,AOX1 |
| Cytokine-cytokine receptor interaction | CCL3L1,CX3CL1,IFNB,TNFSF15,Ccl9,TNFRSF21,TNFSF9,IL17B,HGF,Il23a; Il12b |
| Neuroactive ligand-receptor interaction | NTSR2,NPBWR2,GALR1,TAAR13B,CHRNA6,AVPR1B,HTR1A,TRY,EDNRB2,LHCGR |
Protein Function
GHR has several biochemical functions, for example, cytokine receptor activity,growth factor binding,peptide hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GHR itself. We selected most functions GHR had, and list some proteins which have the same functions with GHR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine receptor activity | IL12RB1,Il4ra,LEPR,CRFB17,IL17RB,IL11RA,PRLRA,F3,IL2RGB,CRFB16 |
| protein kinase binding | TRIB3,SOCS1,TEX14,GCSAM,CCNE1,RHEB,USP37,RPS3,RFFL,PXN |
| peptide hormone binding | ECE1,NPR1,CRHR2,PTH1RA,AGTR1B,NPR2,INHBA,RXFP2,PRLR,MC3R |
| growth factor binding | RPL37,RHBDF1,REG3B,FLT4,NRP1,ACVR2B,LTBP2,IGFBP2B,A2M,GHRHR |
| protein homodimerization activity | HINT2,LMLN,IKZF3,ERCC5,CHMP4A,TERT,HER5,MID1,LHPP,STC2 |
| proline-rich region binding | ABI2,NEDD4,CYLD,YAP1,PRPF40A,PFN1,TCERG1,CCND1,WBP4,APBB1 |
| protein binding | IGBP1,ARHGDIG,CCNDBP1,TERT,DNMT1,CATSPERB,CDK18,LSM11,TSNAX,CPNE3 |
Interacting Protein
GHR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GHR here. Most of them are supplied by our site. Hope this information will be useful for your research of GHR.
PTPRB;PTPN2;PTPN1;PTPN3
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References
- Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
- Beckwith, H; Yee, D; et al. INSULIN-LIKE GROWTH FACTORS, INSULIN, AND GROWTH HORMONE SIGNALING IN BREAST CANCER: IMPLICATIONS FOR TARGETED THERAPY. ENDOCRINE PRACTICE 20:1214-1221(2014).
