Recombinant Human GHR, His-tagged, Biotinylated
Cat.No. : | GHR-254H |
Product Overview : | Human GHR Protein, Biotinylated (Biotinylated GHR) Ala 27 - Tyr 264, was labeled with biotin based on rhGHR Protein, which was produced in human 293 cells (HEK293). |
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Species : | Human |
Source : | HEK293 |
Tag : | His |
Protein Length : | 27-264 a.a. |
Description : | This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose are added as protectants before lyophilization. |
Molecular Mass : | Biotinylated GHR, fused with 6×His tag at the C-terminus, has a calculated MW of 28.5 kDa. The predicted N-terminus is Ala 27. DTT-reduced Protein migrates as 40-50 kDa due to glycosylation. |
Endotoxin : | Less than 1.0 EU per μg of the Biotinylated GHR by the LAL method. |
Purity : | >95% as determined by reduced SDS-PAGE. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). |
Gene Name | GHR growth hormone receptor [ Homo sapiens ] |
Official Symbol | GHR |
Synonyms | GHR; growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein; GHBP; |
Gene ID | 2690 |
mRNA Refseq | NM_000163 |
Protein Refseq | NP_000154 |
MIM | 600946 |
UniProt ID | P10912 |
Chromosome Location | 5p14-p12 |
Pathway | Androgen Receptor Signaling Pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem; Growth hormone receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem; |
Function | SH2 domain binding; growth factor binding; growth hormone receptor activity; peptide hormone binding; proline-rich region binding; protein binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; receptor activity; |
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Not For Human Consumption!
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