Recombinant Rat Growth Hormone Receptor

Cat. No. :	Ghr-1792R
Description :	Growth hormone receptor, also known as GHR is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature (proportional dwarfism).
Molecular Weight :	The predicted molecular weight of Recombinant Rat GHR is Mr 55.1 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 65-80 kDa.
Source :	Mammalian cells
State Of Matter :	Lyophilized.
Purity :	>90% by SDS Page and analyzed by silver stain.
Endotoxin :	<1.0 EU/µg as determined by the LAL method.
Storage And Stability :	This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Tag :	Non

Gene Name	Ghr growth hormone receptor [ Rattus norvegicus ]
Synonyms	Ghr; growth hormone receptor; GHR/BP; MGC124963; MGC156665; growth hormone receptor/binding protein
Gene ID	25235
mRNA Refseq	NM_017094
Protein Refseq	NP_058790
UniProt ID	P16310
Chromosome Location	2q16
Pathway	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Neuroactive ligand-receptor interaction
Function	SH2 domain binding; growth hormone receptor activity; peptide hormone binding; phosphate binding; protein binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; receptor activity