CLEC4E
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Official Full Name
C-type lectin domain family 4, member E -
Overview
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. -
Synonyms
CLEC4E;C-type lectin domain family 4, member E;C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , CLECSF9;C-type lectin domain family 4 member E;mincle;C type lectin domain family 4 member E;C type lectin superfamily member 9;C-type (calcium dependent carbohydrate recognition domain) lectin superfamily member 9;CLEC 4E;CLECSF9;Macrophage inducible C type lectin;OTTHUMP00000239175;OTTHUMP00000239177;C-type lectin superfamily member 9;macrophage-inducible C-type lectin;C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9
Recombinant Proteins
- Mouse
- Rhesus macaque
- Rat
- Human
- Cynomolgus
- CHO
- HEK293
- Mammalian Cell
- Wheat Germ
- E.coli
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- Fc
- His
- GST
- Non
- Flag
- His&Strep
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CLEC4E involved in several pathways and played different roles in them. We selected most pathways CLEC4E participated on our site, such as Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC4E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tuberculosis | PMAP-36,IFNG,PIK3C3,BAD,CAMK2D,ARHGEF12,ATP6V0D1,H2-AA,NFYC,CD209A |
Protein Function
CLEC4E has several biochemical functions, for example, carbohydrate binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC4E itself. We selected most functions CLEC4E had, and list some proteins which have the same functions with CLEC4E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | JMJD6,VMN1R44,ITGB3A,NLGN4X,CRTAM,P2RY2,NLGN2,FKBP3,CADM3,TNFRSF13B |
| carbohydrate binding | ACAN,SFTPD,CLEC5A,CLEC2D,C15orf24,PKD1,CLEC2B,LGALS7B,CD72,GALNTL4 |
Interacting Protein
CLEC4E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC4E here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC4E.
Resources
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References
- Kataoka, H; Kono, H; et al. Evaluation of the Contribution of Multiple DAMPs and DAMP Receptors in Cell Death-Induced Sterile Inflammatory Responses. PLOS ONE 9:-(2014).
- Zhao, XQ; Zhu, LL; et al. C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6 '-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-kappa B Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:30052-30062(2014).
