Recombinant Human CLEC4E Protein, GST-tagged

• Cat.No.: CLEC4E-1469H
• Product Overview: Human CLEC4E full-length ORF ( AAH00715, 1 a.a. - 219 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 49.83 kDa
• AA Sequence: MNSSKSSETQCTERGCFSSQMFLWT VAGIPILFLSACFITRCVVTFRIFQ TCDEKKFQLPENFTELSCYNYGSGS VKNCCPLNWEYFQSSCYFFSTDTIS WALSLKNCSAMGAHLVVINSQEEQE FLSYKKPKMREFFIGLSDQVVEGQW QWVDGTPLTKSLSFWDVGEPNNIAT LEDCATMRDSSNPRQNWNDVTCFLN YFRICEMVGINPLNKGKSL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CLEC4E C-type lectin domain family 4, member E [ Homo sapiens ]
• Official Symbol: CLEC4E
• Synonyms: CLEC4E; C-type lectin domain family 4, member E; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , CLECSF9; C-type lectin domain family 4 member E; mincle; C-type lectin superfamily member 9; macrophage-inducible C-type lectin; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9; MINCLE; CLECSF9
• Gene ID: 26253
• mRNA Refseq: NM_014358
• Protein Refseq: NP_055173
• MIM: 609962
• UniProt ID: Q9ULY5

Reviews

10/24/2022

The CLEC4E protein is an exceptional protein solution that exceeds expectations in terms of quality and suitability for my experimental requirements.

01/01/2021

I am confident that utilizing the CLEC4E protein will empower me to uncover crucial insights into cellular mechanisms with precision.

03/11/2020

In addition to its outstanding quality, the CLEC4E protein comes with exceptional technical support from its manufacturer.

Q&As

Can CLEC4E protein be targeted for the treatment of autoimmune diseases?

While the role of CLEC4E in autoimmune diseases is still being investigated, targeting CLEC4E may hold potential for modulating immune responses in certain autoimmune conditions.

How does CLEC4E protein contribute to immune responses?

CLEC4E protein activates immune cells and initiates inflammatory responses upon recognition of pathogen-associated molecular patterns (PAMPs).

Is CLEC4E protein involved in antiviral immune responses?

Yes, CLEC4E is involved in recognizing viral pathogens and triggering immune responses to combat viral infections.

How does CLEC4E protein interact with other immune receptors?

CLEC4E can collaborate with other immune receptors, such as TLRs (Toll-like receptors), to amplify immune responses upon pathogen detection.

Are there any specific diseases where targeting CLEC4E shows promise?

Targeting CLEC4E holds promise in the development of vaccines and immunotherapies against infectious diseases, including tuberculosis and fungal infections.