Recombinant Human CLEC4E Protein, Myc/DDK-tagged

• Cat.No.: CLEC4E-7778H
• Product Overview: Recombinant protein of human C-type lectin domain family 4, member E (CLEC4E) with a C-Myc/DDK tag was expressed in HEK293T.

Specification

• Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
• Source: HEK293T
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 24.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: CLEC4E C-type lectin domain family 4 member E [ Homo sapiens (human) ]
• Official Symbol: CLEC4E
• Synonyms: CLEC4E; C-type lectin domain family 4 member E; MINCLE; CLECSF9; C-type lectin domain family 4 member E; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9; C-type lectin superfamily member 9; macrophage-inducible C-type lectin
• Gene ID: 26253
• mRNA Refseq: NM_014358
• Protein Refseq: NP_055173
• MIM: 609962
• UniProt ID: Q9ULY5

Reviews

10/24/2022

The CLEC4E protein is an exceptional protein solution that exceeds expectations in terms of quality and suitability for my experimental requirements.

01/01/2021

I am confident that utilizing the CLEC4E protein will empower me to uncover crucial insights into cellular mechanisms with precision.

03/11/2020

In addition to its outstanding quality, the CLEC4E protein comes with exceptional technical support from its manufacturer.

Q&As

Can CLEC4E protein be targeted for the treatment of autoimmune diseases?

While the role of CLEC4E in autoimmune diseases is still being investigated, targeting CLEC4E may hold potential for modulating immune responses in certain autoimmune conditions.

How does CLEC4E protein contribute to immune responses?

CLEC4E protein activates immune cells and initiates inflammatory responses upon recognition of pathogen-associated molecular patterns (PAMPs).

Is CLEC4E protein involved in antiviral immune responses?

Yes, CLEC4E is involved in recognizing viral pathogens and triggering immune responses to combat viral infections.

How does CLEC4E protein interact with other immune receptors?

CLEC4E can collaborate with other immune receptors, such as TLRs (Toll-like receptors), to amplify immune responses upon pathogen detection.

Are there any specific diseases where targeting CLEC4E shows promise?

Targeting CLEC4E holds promise in the development of vaccines and immunotherapies against infectious diseases, including tuberculosis and fungal infections.