CCL18
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Official Full Name
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) -
Overview
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. -
Synonyms
CCL18;chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated);CKb7;PARC;AMAC1;DCCK1;MIP-4;AMAC-1;DC-CK1;SCYA18;C-C motif chemokine 18;CC chemokine PARC;OTTHUMP00000163954;CC chemokine ligand 18;chemokine (C-C), dendritic;dendritic cell chemokine 1;small inducible cytokine A18;small-inducible cytokine A18;macrophage inflammatory protein 4;pulmonary and activation-regulated chemokine;alternative macrophage activation-associated CC chemokine 1;small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
Recombinant Proteins
- Human
- Rhesus macaque
- CHO
- E.coli
- Wheat Germ
- Yeast
- Mammalian Cell
- Mammalian cells
- Human Cells
- HEK293T
- HEK293
- In Vitro Cell Free System
- Non
- Fc
- His
- GST
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CCL18 involved in several pathways and played different roles in them. We selected most pathways CCL18 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | FLT3,TGFB3,TNFRSF14,Il4ra,FLT4,TNFRSF12A,CCL11,IL17B,FAS,CXCR3.1 |
| Chemokine signaling pathway | GNB2,RAP1A,CCL4,STAT3,GM13304,CRKL,Cxcl15,GNG3,GNB1,GNAI3 |
Protein Function
CCL18 has several biochemical functions, for example, CCR chemokine receptor binding,chemokine activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL18 itself. We selected most functions CCL18 had, and list some proteins which have the same functions with CCL18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemokine activity | CXCL11,CXCL12B,Ccl12,CXCL19,CCL19,Ccl21c,CXL34B.11,CCL5,CXCL3,CXCL12A |
| protein binding | HSPA1A,KIFAP3,THY1,ATP6V1C1,MRPL23,SUN1,ZFP64,CEP290,TFDP2,ELF2 |
| CCR chemokine receptor binding | CCL19A.1,CCL19B,CCL20,CCRL2,CCL38A.5,CCL20B,CCL25B,CCL38.1,CCL24,CCL34B.1 |
Interacting Protein
CCL18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL18 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL18.
PITPNM3;TP53;EEF1A1;TLE1;UNC119;CRMP1;C14orf1
Resources
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References
- Suga, H; Sugaya, M; et al. The Role of IL-32 in Cutaneous T-Cell Lymphoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:1428-1435(2014).
- Xu, Y; Zhang, L; et al. CC Chemokine Ligand 18 and IGF-Binding Protein 6 as Potential Serum Biomarkers for Prostate Cancer. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 233:25-31(2014).
