B2M
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Official Full Name
beta-2-microglobulin -
Overview
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. -
Synonyms
B2M;beta-2-microglobulin;Beta-2-microglobulin;beta chain of MHC class I molecules;beta-2-microglobin
Recombinant Proteins
- Human
- Rat
- Chicken
- Cynomolgus
- Dog
- Mouse
- Cynomolgus/Rhesus macaque
- Zebrafish
- Hamster
- Sheep
- Rhesus macaque
- Pig
- Golden hamster
- Pongo pygmaeus
- E.coli
- HEK293
- E. coli
- Wheat Germ
- Mammalian Cell
- Insect Cell
- Human
- HEK293F
- Yeast
- Human Cell
- CHO
- Mammalian cells
- Human Tissue
- In Vitro Cell Free System
- Human urine frompatients with tubular proteinuria
- HEK293T
- Human Urine
- GST
- His
- N-His
- Flag
- Non
- His&GST
- Fc
- His&Strep
- Myc&DDK
- His&Myc
- His&Avi
- His&Fc&Avi
Involved Pathway
B2M involved in several pathways and played different roles in them. We selected most pathways B2M participated on our site, such as Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with B2M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | CD74,CTSB,KLRD1,LGMN,HLA-F,IFNG,CTSS,PSME2,KIR2DL4,TNF |
Protein Function
B2M has several biochemical functions, for example, glycoprotein binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by B2M itself. We selected most functions B2M had, and list some proteins which have the same functions with B2M. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycoprotein binding | TGFB1,Shh,FBXO17,CANX,Serpina1c,IGF2R,ITGA3,EDEM2,VLDLR,LACRT |
| protein binding | SECISBP2,ECD,KANSL2,PHOSPHO2,LITAF,FAM90A1,RFPL4,USP46,RPL7,TSHR |
| identical protein binding | HOOK1,TPCN1,GRIK5,RUNX1T1,UBQLN1,GYPA,PRPS2,MNS1,CCT7,IAPP |
Interacting Protein
B2M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B2M here. Most of them are supplied by our site. Hope this information will be useful for your research of B2M.
HFE;CD1A;CD1B;HLA-A
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References
- Oliveira, AC; de Sevilla, AF; et al. Prospective study of prognostic factors in asymptomatic patients with B-cell chronic lymphocytic leukemia-like lymphocytosis: the cut-off of 11 x 10(9)/L monoclonal lymphocytes better identifies subgroups with different outcomes. ANNALS OF HEMATOLOGY 94:627-632(2015).
- Park, SJ; Kwon, SG; et al. Selection of appropriate reference genes for RT-qPCR analysis in Berkshire, Duroc, Landrace, and Yorkshire pigs. GENE 558:152-158(2015).
