APOA1
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Official Full Name
apolipoprotein A-I -
Overview
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008] -
Synonyms
APOA1;apolipoprotein A-I;apo-AI;Sep2;Alp-1;Ltw-1;Sep-1;Sep-2;Apoa-1;Brp-14;Lvtw-1
Recombinant Proteins
- Human
- Dog
- Pig
- Rabbit
- Cynomolgus
- Mouse
- Chicken
- Rat
- Bovine
- Chimpanzee
- E.coli
- HEK293
- Dog
- Mammalian Cell
- Wheat Germ
- Human Cell
- Mammalian cells
- Human cells
- In Vitro Cell Free System
- Yeast
- Human Plasma HDL
- HEK293T
- Human Plasma
- Human Serum
- Human plasma
- Non
- Fc
- GST
- His
- His&GST
- Myc&DDK
- His&B2M
- His&Fc&Avi
- N-His&C-Myc
- Flag
Involved Pathway
APOA1 involved in several pathways and played different roles in them. We selected most pathways APOA1 participated on our site, such as PPAR signaling pathway,Fat digestion and absorption,Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vitamin digestion and absorption | SLC5A6,SLC46A1,TCN2,APOB,MMACHC,SCARB1,CUBN,SLC19A3,PNLIP,ABCC1 |
| Fat digestion and absorption | PLA2G2A,PPAP2C,APOA4,APOB,AGPAT2,ACAT2,SCARB1,PLA2G2F,CLPS,FABP2 |
| African trypanosomiasis | PRKCB,PLCB3,HBB-B1,IL10,HBA2,F2RL1,THOP1,LAMA4,IL6,FAS |
| PPAR signaling pathway | FABP7B,FABP1,ACSL3B,ACSBG2,CYP4A10,ACSL1B,PCK1,FABP7,CPT1C,RXRGA |
Protein Function
APOA1 has several biochemical functions, for example, apolipoprotein A-I receptor binding,apolipoprotein receptor binding,beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOA1 itself. We selected most functions APOA1 had, and list some proteins which have the same functions with APOA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | VPS4B,MYOM1,GLE1,NCL,CLDN2,KHDC1A,SUN2,SF1,UGP2,ASS1 |
| beta-amyloid binding | BCHE,CST3,APOE,APOEA,TGFB2,APBA3,APBA2,TM2D1,CHRNA7,GPRASP2 |
| contributes_to cholesterol transporter activity | ABCG5,ABCG8,SFRP5,APOA2 |
| enzyme binding | RCOR2,UGT1A1,ADORA2A,NKX2-1,NR5A1,DDC,UBE2L3,SCNM1,NOS1,TSPAN5 |
| phospholipid binding | ARHGAP44,APOEA,NSFL1C,TEC,APOA2,ANXA9,PICALMA,APOB,APOC3,APOEB |
| cholesterol transporter activity | APOEA,APOA1A,APOE,APOA4A,ABCA4A,APOA4B.1,ABCA7,APOA4,APOA4B.2,APOA5 |
| chemorepellent activity | SEMA6E,SEMA3BL,SEMA3D,SEMA3AA,SEMA4B,SEMA3FA,SEMA3B,SEMA6C,SEMA6A,SEMA4D |
| high-density lipoprotein particle binding | GPIHBP1,APOA1A,APOA2,APOL2 |
| protein binding | KCNIP3,NAT8,PDIA4,WBP11,TOMM7,STAT5B,TSPAN1,GZMM,PRPF31,PCMT1 |
Interacting Protein
APOA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOA1.
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References
- Verhoeven, V; Van der Auwera, A; et al. Can red yeast rice and olive extract improve lipid profile and cardiovascular risk in metabolic syndrome?: a double blind, placebo controlled randomized trial. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 15:-(2015).
- Liting, P; Guoping, L; et al. Apolipoprotein B/apolipoprotein A1 ratio and non-high-density lipoprotein cholesterol Predictive value for CHD severity and prognostic utility in CHD patients. HERZ 40:1-7(2015).
