Acvr1c
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Official Full Name
activin A receptor, type IC -
Overview
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008] -
Synonyms
ACVR1C;activin A receptor, type IC;ALK7;ACVRLK7;activin receptor type-1C;ALK-7;ACTR-IC;activin receptor type IC;activin receptor-like kinase 7
Recombinant Proteins
- Human
- Rat
- Rhesus macaque
- Cynomolgus
- Mouse
- E.coli
- Insect Cells
- Human Cells
- Mammalian Cells
- Wheat Germ
- HEK293
- Sf9 Cells
- Insect cells
- In Vitro Cell Free System
- GST
- His
- Fc
- GST&His
- Non
- Flag
- DDK&Myc
- Fc&His
- Avi&Fc&His
Involved Pathway
Acvr1c involved in several pathways and played different roles in them. We selected most pathways Acvr1c participated on our site, such as Developmental Biology,MAPK signaling pathway,Regulation of signaling by NODAL, which may be useful for your reference. Also, other proteins which involved in the same pathway with Acvr1c were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by NODAL | DRAP1,LEFTY1,CFC1,GDF1,PCSK6,TDGF1,FOXH1 |
| Signaling pathways regulating pluripotency of stem cells | FGFR1,SMAD2,PAX6,WNT7A,PIK3CB,BMP4,FZD3,ID4,BMI1,PCGF2 |
| MAPK signaling pathway | PRKCG,GRB2,TAOK1,RAC3B,IKBKG,FGF6,LRRK2,FASLG,NLK2,FLNC |
| Regulation of signaling by NODAL | LEFTY1,TDGF1,CFC1 |
| Signal Transduction | SPRY1,RDH13,SOUL3,PPY,EVC2,WIPF2,PRKCHB,LINGO1,ARHGAP19,ARHGAP20 |
| Developmental Biology | CDK5R1B,EFNA2A,AP2B1,RASGRP4,CSNK2A2,SCN3A,GPC1A,DOCK1,CDK8,GPC1B |
| TGF-beta signaling pathway | BAMBIA,RPS6KB1B,TGFBR2,INHBA,RBL1,RHOA,NODAL,CHRD,BMPR1BA,IFNG |
| Signaling by Activin | FSTL3,FOXH1,FSTB,INHBAA,FST,DRAP1 |
Protein Function
Acvr1c has several biochemical functions, for example, ATP binding,activin receptor activity, type I,growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Acvr1c itself. We selected most functions Acvr1c had, and list some proteins which have the same functions with Acvr1c. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| activin receptor activity, type I | ACVRL1,ACVR1B |
| nodal binding | CFC1 |
| receptor signaling protein serine/threonine kinase activity | BMPR1BA,BMPR1AA,PAK2B,BMPR1BB,PANK1A,BMPR2,OXSR1A,ACVR2A,TGFB2,ACVR1L |
| ATP binding | SLC14A2,PTK6,TAOK1,GLYCTK,P2RX3,NADK,RTEL1,TRPM4,DARS2,DICER1 |
| metal ion binding | ATMIN,ZBTB26,ZNF280B,CSH2,BRCC3,ZFML,ACSM2B,ZFP2,MOBKL2A,OAS2 |
| growth factor binding | LIFR,LTBP4,OSMR,GHR,SDCBP,FGFBP2,ERBB3,RPL37,NRP2,FLT1 |
Interacting Protein
Acvr1c has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Acvr1c here. Most of them are supplied by our site. Hope this information will be useful for your research of Acvr1c.
b4dyc6_human;HSP90AB1;INHBB
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