Recombinant Human ALK7, GST-tagged

• Cat.No.: ALK7-3271H
• Product Overview: ALK7

Specification

• Description: ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.
• Source: Sf9 Insect Cell
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~68 kDa
• Protein length: 135-493aa
• Applications: Western Blot (WB)
• Notes: Small volumes of ALK7 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: ACVR1C activin A receptor, type IC [ Homo sapiens ]
• Official Symbol: ACVR1C
• Synonyms: ALK7; ACVRLK7; activin receptor type-1C; ALK-7; ACTR-IC; activin receptor type IC; activin receptor-like kinase 7
• Gene ID: 130399
• mRNA Refseq: NM_001111031
• Protein Refseq: NP_001104501
• MIM: 608981
• UniProt ID: Q8NER5
• Chromosome Location: 2q24.1
• Pathway: Developmental Biology, organism-specific biosystem; Regulation of Signaling by NODAL, organism-specific biosystem
• Function: ATP binding; metal ion binding