UNG
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Official Full Name
uracil-DNA glycosylase -
Overview
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010] -
Synonyms
UNG;uracil-DNA glycosylase;DGU;UDG;UNG1;UNG2;HIGM4;HIGM5;UNG15;uracil-DNA glycosylase 1, uracil-DNA glycosylase 2
Recombinant Proteins
- Human
- E.coli
- Bacillus subtilis
- Mouse
- Chicken
- Rat
- E.coli
- E. coli or Yeast
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- Non
- GST
- His
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
UNG involved in several pathways and played different roles in them. We selected most pathways UNG participated on our site, such as Base excision repair,Primary i,nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Primary i | TAP1,RAG2,CD40LG,CD40,CD8B,TNFRSF13B,CD3E,ICOS,DCLRE1C,IGLL1 |
| nodeficiency | CD40LG,CD4,TAP1,IL7R,CD8B1,RAG2,IL2RG,AICDA,RAG1,TNFRSF13B |
| Base excision repair | POLD1,POLE2,HMGB1B,POLE,PCNA,PARP4,POLL,NEIL3,OGG1,NEIL2 |
Protein Function
UNG has several biochemical functions, for example, damaged DNA binding,protein binding,uracil DNA N-glycosylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UNG itself. We selected most functions UNG had, and list some proteins which have the same functions with UNG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| uracil DNA N-glycosylase activity | SMUG1,TDG.1,TDG,UNGA,APEX1,CCNO |
| damaged DNA binding | APEX1,RBBP8,XPA,TDG,FEN1,DCLRE1A,DCLRE1C,TRP63,PCNA,ERCC3 |
| protein binding | DDX6,HIST1H1E,CFH,FAM72A,ARFGAP3,VASNA,PLUNC,S100A8,CYSLTR2,RANBP6 |
Interacting Protein
UNG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNG here. Most of them are supplied by our site. Hope this information will be useful for your research of UNG.
RPA2;UGI;4505953;vpr;SEZ6L2;CAPN11;vpr;k7_vaccw;Ppp2r2d;vpr
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References
- Pettersen, HS; Galashevskaya, A; et al. AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA REPAIR 25:60-71(2015).
- White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).
