TNFRSF8

  • Official Full Name

    Tumor Necrosis Factor Receptor Superfamily, Member 8

  • Overview

    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

  • Synonyms

    CD 30;CD153 antibodyCD30;CD30 antigen;CD30L receptor;Cytokine receptor CD30;D1S166E;KI 1;Ki-1 antigen;KI1;Lymphocyte activation;antigen CD30;TNFRSF8;Tumor Necrosis Factor Receptor Superfamily Member 8;Iratumumab;640735-09-7;914088-09-8;CD30;Ki-1

Recombinant Proteins

  • Human
  • Cynomolgus
  • Rhesus macaque
  • Mouse
  • Chicken
  • Rat
  • Canine
  • Mammalian Cells
  • Human Cells
  • E.coli
  • HEK293
  • Wheat Germ
  • Insect Cells
  • Sf9 Cells
  • Insect cells
  • Fc
  • His
  • Fc&His
  • Avi&His
  • Avi&Fc
  • Non
  • hIgG4
  • Flag
  • Flag&His
  • Avi&Fc&His
  • DDK&Myc
  • lIgG2b
  • GST&His
  • mFc
Cat.# Product name Source (Host) Species Tag Protein Length Price
TNFRSF8-1594HAF488 Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian Cells Human Fc 1-379 a.a.
TNFRSF8-1594HAF555 Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian Cells Human Fc 1-379 a.a.
TNFRSF8-1594HAF647 Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian Cells Human Fc 1-379 a.a.
TNFRSF8-1594HF Active Recombinant Human TNFRSF8 Protein, Fc-tagged, FITC conjugated Mammalian Cells Human Fc 1-379 a.a.
TNFRSF8-263HAF488 Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian Cells Human Fc
TNFRSF8-263HAF555 Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian Cells Human Fc
TNFRSF8-263HAF647 Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian Cells Human Fc
TNFRSF8-263HF Active Recombinant Human TNFRSF8 Protein, Fc-tagged, FITC conjugated Mammalian Cells Human Fc
TNFRSF8-563H Recombinant Human TNFRSF8, His tagged Human Cells Human His 1-379 a.a.
TNFRSF8-642H Active Recombinant Human TNFRSF8, Fc-His tagged Human Cells Human Fc&His 1-379 a.a.
TNFRSF8-2788H Recombinant Human TNFRSF8 protein, His-tagged E.coli Human His 19-246 aa
TNFRSF8-563HAF488 Recombinant Human TNFRSF8 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 372
TNFRSF8-563HAF555 Recombinant Human TNFRSF8 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 372
TNFRSF8-563HAF647 Recombinant Human TNFRSF8 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Human His 372
TNFRSF8-563HF Recombinant Human TNFRSF8 Protein, His-tagged, FITC conjugated HEK293 Human His 372
TNFRSF8-641HAF488 Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc Phe 19-Lys 379
TNFRSF8-641HAF555 Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc Phe 19-Lys 379
TNFRSF8-641HAF647 Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc Phe 19-Lys 379
TNFRSF8-641HF Recombinant Human TNFRSF8 Protein, Fc-tagged, FITC conjugated HEK293 Human Fc Phe 19-Lys 379
TNFRSF8-642HAF488 Recombinant Human TNFRSF8 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc&His 609
TNFRSF8-642HAF555 Recombinant Human TNFRSF8 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc&His 609
TNFRSF8-642HAF647 Recombinant Human TNFRSF8 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc&His 609
TNFRSF8-642HF Recombinant Human TNFRSF8 Protein, Fc/His-tagged, FITC conjugated HEK293 Human Fc&His 609
TNFRSF8-1821H Recombinant Human TNFRSF8 protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His Phe19-Lys379
CD30-3072H Active Recombinant Human CD30 protein, His-tagged, FITC-Labeled HEK293 Human His Phe 19-Lys 379
CD30-3074H Active Recombinant Human CD30 protein, Fc-tagged,FITC-Labeled HEK293 Human Fc Phe 19-Lys 379
TNFRSF8-046C Recombinant Cynomolgus TNFRSF8 protein, His-tagged HEK293 Cynomolgus His Ala27-Pro394
TNFRSF8-051H Active Recombinant Human TNFRSF8 protein, His/Avi-tagged, Biotinylated HEK293 Human Avi&His Phe19-Lys379
TNFRSF8-052H Active Recombinant Human TNFRSF8 protein, Fc/Avi-tagged, Biotinylated HEK293 Human Avi&Fc Phe19-Lys379
TNFRSF8-973H Active Recombinant Human TNFRSF8 Protein, His & hFc-tagged HEK293 Human Fc&His Met 1-Lys 379
TNFRSF8-642HP Recombinant Human TNFRSF8 protein, Fc-His-tagged, R-PE labeled HEK293 Human Fc&His
TNFRSF8-1594H Active Recombinant Human TNFRSF8, Fc-tagged Mammalian Cells Human Fc 1-379 a.a.
TNFRSF8-1691R Recombinant Rhesus Monkey TNFRSF8 Protein HEK293 Rhesus macaque Non 29-393 a.a.
Tnfrsf8-1713M Recombinant Mouse Tnfrsf8 Mammalian Cells Mouse Non
TNFRSF8-1720R Recombinant Rhesus Monkey TNFRSF8 Protein, hIgG1-tagged HEK293 Rhesus macaque Fc 29-393 a.a.
TNFRSF8-1721R Recombinant Rhesus Monkey TNFRSF8 Protein, hIgG4-tagged HEK293 Rhesus macaque hIgG4 29-393 a.a.
TNFRSF8-26927TH Recombinant Human TNFRSF8 Wheat Germ Human Non 113 amino acids
TNFRSF8-377H Recombinant Human TNFRSF8 Protein, His-tagged Insect Cells Human His
TNFRSF8-6014C Recombinant Chicken TNFRSF8 Mammalian Cells Chicken His
TNFRSF8-6201R Recombinant Rat TNFRSF8 Protein Mammalian Cells Rat His
TNFRSF8-641H Recombinant Human TNFRSF8 protein, hFc-tagged HEK293 Human Fc Phe19-Lys379
TNFRSF8-7532H Recombinant Human TNFRSF8, His-tagged E.coli Human His 19-379aa
TNFRSF8-889H Recombinant Human TNFRSF8 Protein, DDK-tagged Sf9 Cells Human Flag -19 a.a.
TNFRSF8-2097HCL Recombinant Human TNFRSF8 cell lysate Human Cells Human Non
CD30-3073C Recombinant Canine CD30 protein, His-tagged HEK293 Canine His Met 1-Gly 284
CD30-492M CD30 protein-coupled magnetic MicroBeads Human
RFL12946RF Recombinant Full Length Rat Tumor Necrosis Factor Receptor Superfamily Member 8(Tnfrsf8) Protein, His-Tagged E.coli Rat His Full L. Full Length of Mature Protein (19-493)
RFL31646HF Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 8(Tnfrsf8) Protein, His-Tagged E.coli Human His Full L. Full Length of Mature Protein (19-595)
Tnfrsf8-006M Recombinant Mouse Tnfrsf8 Protein, hIgG/His-tagged Insect Cells Mouse Fc&His 19-258aa
TNFRSF8-0270H Recombinant Human TNFRSF8 protein, His&Avi-tagged, Biotinylated HEK293 Human Avi&His 1-379 a.a.
TNFRSF8-0272H Recombinant Human TNFRSF8 protein, His-tagged, Biotinylated HEK293 Human His Met1-Lys379
Tnfrsf8-038M Recombinant Mouse Tnfrsf8 Protein, hIgG/His-tagged Insect cells Mouse Fc&His
TNFRSF8-045C Recombinant Cynomolgus TNFRSF8 protein, His-tagged HEK293 Cynomolgus His Met1-Gly194
Tnfrsf8-058M Recombinant Mouse Tnfrsf8 Protein, hFc-tagged HEK293 Human Fc Met1-Thr258
TNFRSF8-08H Recombinant Human TNFRSF8 Protein, C-6His-Avi tagged, Biotinylated Human Cells Human Avi&His Gln24-Lys265(Met115Thr)
TNFRSF8-090H Recombinant Human tumor necrosis factor receptor superfamily, member 8 Protein, His&Flag tagged HEK293 Human Flag&His 19-385aa
Tnfrsf8-10625M Recombinant Mouse Tnfrsf8 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
Tnfrsf8-10625M-B Recombinant Mouse Tnfrsf8 Protein Pre-coupled Magnetic Beads HEK293 Mouse
TNFRSF8-1155M Recombinant Mouse TNFRSF8 Protein (Met1-Thr258), His-tagged HEK293 Mouse His Met1-Thr258
TNFRSF8-1156M Recombinant Mouse TNFRSF8 protein(Met1-Thr258), hFc-tagged HEK293 Mouse Fc Met1-Thr258
TNFRSF8-145H Recombinant Human TNFRSF8 Protein, His-tagged HEK293 Human His 595
TNFRSF8-146H Recombinant Human TNFRSF8 Protein, Fc-tagged HEK293 Human Fc 595
TNFRSF8-150H Recombinant Human TNFRSF8 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
TNFRSF8-150H-B Recombinant Human TNFRSF8 Protein Pre-coupled Magnetic Beads HEK293 Human
TNFRSF8-1594HA Recombinant Human TNFRSF8 protein, Fc-tagged, APC labeled Mammalian Cells Human Fc
TNFRSF8-1594HP Recombinant Human TNFRSF8 protein, Fc-tagged, R-PE labeled HEK293 Human Fc Met1-Lys379
TNFRSF8-180H Recombinant Human TNFRSF8 Protein, His\Avi-tagged Human Cells Human Avi&His 24-265 a.a.
TNFRSF8-2027H Recombinant Human TNFRSF8 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
TNFRSF8-2031H Recombinant Human TNFRSF8 Protein, DDK-tagged Insect Cells Human Flag
TNFRSF8-2405M Recombinant Mouse TNFRSF8 protein(Met1-Thr258), hFc-tagged HEK293 Mouse Fc Met1-Thr258
TNFRSF8-2637H Active Recombinant Human TNFRSF8 protein, His-tagged HEK293 Human His Phe19-Lys379
TNFRSF8-373H Active Recombinant Human TNFRSF8 Protein, LIgG2b Fc-tagged, low endotoxin HEK293 Human lIgG2b Phe 19 - Lys 379
TNFRSF8-434H Recombinant Human TNFRSF8 Protein (Met1-Lys379), His-tagged, Biotinylated HEK293 Human His Met1-Lys379
TNFRSF8-444H Recombinant Human TNFRSF8 protein, His-Avi-tagged HEK293 Human Avi&His Phe19-Lys379
TNFRSF8-451H Recombinant Human TNFRSF8 Protein, His-tagged E.coli Human His Met464-Lys595
Tnfrsf8-452R Recombinant Rat Tnfrsf8 Protein, His&GST-tagged E.coli Rat GST&His Asn43-Leu201
TNFRSF8-4659H Active Recombinant Human TNFRSF8 Protein, His-tagged, Site-specific PE-Labeled HEK293 Human His Phe 19 - Lys 379
TNFRSF8-5335H Recombinant Human TNFRSF8 Protein (Met1-Lys379), C-His tagged Mammalian Cells Human His Met1-Lys379
TNFRSF8-561H Recombinant Human TNFRSF8 Protein (Phe19-Lys379), C-6×His-tagged HEK293 Human His Phe19-Lys379
TNFRSF8-567HG Active GMP Recombinant Human TNFRSF8 protein HEK293 Human DNA sequence encoding Human CD30(UniProtKB - P28908 ) was expressed with His tag at the C-terminal.
TNFRSF8-5858R Recombinant Rat TNFRSF8 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
TNFRSF8-5858R-B Recombinant Rat TNFRSF8 Protein Pre-coupled Magnetic Beads HEK293 Rat
TNFRSF8-641HA Recombinant Human TNFRSF8 protein, Fc-tagged, APC labeled HEK293 Human Fc Met1-Lys379
TNFRSF8-641HP Recombinant Human TNFRSF8 protein, Fc-tagged, R-PE labeled HEK293 Human Fc
TNFRSF8-642HA Recombinant Human TNFRSF8 protein, Fc-His-tagged, APC labeled HEK293 Human Fc&His
Tnfrsf8-6549M Recombinant Mouse Tnfrsf8 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
TNFRSF8-908H Recombinant Human TNFRSF8 protein, mFc-tagged HEK293 Human mFc Phe19-Lys379

    Involved Pathway

    TNFRSF8 involved in several pathways and played different roles in them. We selected most pathways TNFRSF8 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CXCR1,CCL23,TNFRSF9A,CCL11,CXCL6,IFNA1,Flt3l,IL5RA,MPL,TNFRSF10C

    Protein Function

    TNFRSF8 has several biochemical functions, for example, transmembrane signaling receptor activity,tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF8 itself. We selected most functions TNFRSF8 had, and list some proteins which have the same functions with TNFRSF8. You can find most of the proteins on our site.

    Function Related Protein
    transmembrane signaling receptor activity CR2,CELSR1,OR4D2,THBD,FZD9B,SIGLEC8,MRC1,SLAMF1,VIPR1B,LGR6
    tumor necrosis factor-activated receptor activity TNFRSF9,TNFRSF11A,TNFRSF14,TNFRSF10A,TNFRSF10C,NGFR,TNFRSF11B,TNFRSF18,TNFRSF9A,EDA2R

    Interacting Protein

    TNFRSF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF8.

    Traf1;Traf2;BCL6

    TNFRSF8 Related Signal Pathway

    Resources

    Research Area

    Cancer Drug Targets
    Natural Killer Cell (NK Cell)
    Embryonic and Induced Pluripotent Stem Cell Markers
    Co-stimulatory TNF Superfamily Molecules
    CD Antigen (Dendritic Cell Co-stimulatory Molecules)
    CD Antigen (Helper T Cells)
    TNF Receptor
    Co-stimulatory Molecules
    T Follicular Helper (Tfh) Cells
    CAR-T Cell Therapy Targets

    References

    • Slack, GW; Steidl, C; et al. CD30 expression in de novo diffuse large B-cell lymphoma: a population-based study from British Columbia. BRITISH JOURNAL OF HAEMATOLOGY 167:608-617(2014).
    • Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).

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