Recombinant Mouse Tnfrsf8

• Cat.No.: Tnfrsf8-1713M

Specification

• Species: Mouse
• Source: Mammalian Cells
• Tag: Non
• Description: CD30/TNFRSF8, a type I transmembrane glycoprotein belonging to the TNF receptor superfamily and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. CD30 is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma but not in seminoma and is thus is a useful marker in distinguishing between these germ cell tumors.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse CD30 is Mr 55 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 90-100 kDa.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 [ Mus musculus ]
• Synonyms: Tnfrsf8; tumor necrosis factor receptor superfamily, member 8; Ki; Cd30; Ki-1; D1S166E; RP23-306F22.1; OTTMUSP00000010648; CD30
• Gene ID: 21941
• mRNA Refseq: NM_009401
• Protein Refseq: NP_033427
• UniProt ID: Q60846
• Chromosome Location: 4 E1; 4 75.5 cM
• Pathway: Cytokine-cytokine receptor interaction
• Function: receptor activity; transmembrane receptor activity