SFN
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Official Full Name
SFN stratifin -
Overview
Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. Evidence indicates 14-3-3 is required for Raf 1 kinase activity and phosphorylation amoung many other functions. -
Synonyms
SFN;stratifin;14-3-3 protein sigma;14 3 3 sigma;YWHAS;14-3-3 sigma;epithelial cell marker protein 1
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Insect Cell
- Mammalian Cell
- Human
- HEK293
- HEK293T
- E. coli
- Mammalian cells
- GST
- Non
- His
- His&Fc&Avi
- Myc&DDK
- N-His-GST&C-Myc
- N-His&C-Myc
- Flag
Involved Pathway
SFN involved in several pathways and played different roles in them. We selected most pathways SFN participated on our site, such as Cell cycle,p signaling pathway,Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SFN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aldosterone-regulated sodium reabsorption | PRKCB,MAPK3,KCNJ1,PIK3CB,IGF1,NEDD4L,ATP1A1,ATP1A4,INS1,ALPHA-ENAC |
| Cell cycle | E2F4,LMNB1,ARF1,STAG2,ARPP19A,CEP78,CDC7,BUB1,CHEK2,ORC2L |
| p signaling pathway | CCNB2,SIAH2L,TP53AIP1,CCNG1,CASP8,BBC3,SHISA5,TSC2,LRDD,GADD45AA |
Protein Function
SFN has several biochemical functions, for example, phosphoprotein binding,protein binding,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SFN itself. We selected most functions SFN had, and list some proteins which have the same functions with SFN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | LIPE,AKAP5,CNTLN,DUSP3,AGAP2,MS4A2,CDKN2D,BCL2L1,PTPN6,FAF1 |
| protein kinase C inhibitor activity | YWHAG,HSPB1 |
| phosphoprotein binding | APTX,SRC,PITX2,MID1,GPRIN1,DPYS,CBX4,RB1,YWHAE,DPYSL3 |
| protein domain specific binding | YWHAZ,NEDD4,YWHAQB,DDX6,KCTD13,EZR,HIST1H4J,HSPA5,PLAUR,PTPN11 |
| protein binding | ITGAM,KIAA0101,GRIA2,TCEANC2,UBE2O,FLOT2,BNIP1,TLX3,SCG2,SOX1 |
Interacting Protein
SFN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SFN here. Most of them are supplied by our site. Hope this information will be useful for your research of SFN.
EGFR;BAD;RFWD2;HDAC4
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References
- Wu, CC; Chuang, HY; et al. Inhibition of Epstein-Barr Virus Reactivation in Nasopharyngeal Carcinoma Cells by Dietary Sulforaphane. MOLECULAR CARCINOGENESIS 52:946-958(2013).
- Sene, D; Cacoub, P; et al. Sjogren Syndrome-Associated Small Fiber Neuropathy Characterization From a Prospective Series of 40 Cases. MEDICINE 92:E10-E18(2013).
