SEMA4D
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Official Full Name
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -
Overview
May play a functional role in the immune system, as well as in the nervous system. Induces B-cells to aggregate and improves their viability in vitro. -
Synonyms
SEMA4D;sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D;CD100;SEMAJ;coll-4;C9orf164;M-sema-G;semaphorin-4D;A8;GR3;BB18;sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Cynomolgus
- Chicken
- Rat
- HEK293
- CHO
- Mammalian cells
- Mammalian Cell
- E.coli
- Human Cell
- HEK293T
- His
- Fc
- Non
- hIgG4
- His&GST
- His&Fc
- His&Fc&Avi
- His&Avi
- Myc&DDK
Involved Pathway
SEMA4D involved in several pathways and played different roles in them. We selected most pathways SEMA4D participated on our site, such as Axon guidance,Developmental Biology,Other semaphorin interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA4D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | FRS2A,EFNA2A,DUSP2,MED16,ACTR3,MYOG,PEA15A,PTPRA,LGI2A,NTN1A |
| Sema4D induced cell migration and growth-cone collapse | RND1L |
| Sema4D in semaphorin signaling | RND1L |
| Sema4D mediated inhibition of cell attachment and migration | RND1L |
| Semaphorin interactions | SEMA3A,CDK5R1B,PLXND1,CRMP1,DPYSL2,NRP1A,DPYSL5B,PLXNC1,SEMA3AB,DPYSL3 |
| Axon guidance | NCAN,SHB,PPP3CA,Sema3f,GNAI3,EPHB3,ITSN1,SEMA6A,SEMA7A,NTN1 |
| Other semaphorin interactions | PLXND1,PLXNC1 |
Protein Function
SEMA4D has several biochemical functions, for example, chemorepellent activity,NOT neuropilin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA4D itself. We selected most functions SEMA4D had, and list some proteins which have the same functions with SEMA4D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| semaphorin receptor binding | SEMA3FA,SEMA3B,SEMA6C,SEMA4C,SEMA6DL,SEMA3G,SEMA3H,SEMA4BA,SEMA3E,SEMA4A |
| protein binding | CKB,COG5,C22orf29,MCC,THRA,CDON,MELK,ACTR3,CYFIP2,ZSCAN21 |
| NOT neuropilin binding | SEMA4C,SEMA4BA,SEMA4B,SEMA4A |
| receptor activity | NLGN1,ITGB3A,IGSF1,ROBO4,JMJD6,LDLR,ITGB1B.2,CLEC4E,LYVE1,OR3A2 |
| transmembrane signaling receptor activity | ENG,Fzd4,IL27RA,OR103-4,FZD7B,OR6K3,P2RX5,CLEC4A,TNFRSF10C,KLRC2 |
| chemorepellent activity | NRG1,SLIT2,SEMA3D,SEMA6D,SEMA4E,SEMA6DL,SEMA5B,EPHA7,Sema3f,SEMA3C |
| receptor binding | TNFSF9,NPFFL,CCDC129,ICOSLG,NPY,WNT11R,LAMA4,CADM3,HFE2,SCYL2 |
Interacting Protein
SEMA4D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA4D here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA4D.
CRK;PTPRC;ilvD
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