Active Recombinant Human SEMA4D, HIgG1 Fc-tagged

• Cat.No.: SEMA4D-512H
• Product Overview: The extracellular domain of human CD100 (AAH54500.1) (Met22-Arg734) is fused to the N-terminus of the Fc region of human IgG1was expressed in CHO cell

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 22-734 a.a.
• Description: SEMA4D (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D) is a protein-coding gene. Diseases associated with SEMA4D include soft tissue sarcoma, and cleft palate, and among its related super-pathways are Sema4D in semaphorin signaling and Axon guidance. GO annotations related to this gene include transmembrane signaling receptor activity and receptor binding. An important paralog of this gene is SEMA3C.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit survival of SK OV 3 human ovarian carcinoma cells.
• Molecular Mass: 105KDa (monomer)
• AA Sequence: Met22-Arg734
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D [ Homo sapiens ]
• Official Symbol: SEMA4D
• Synonyms: SEMA4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; C9orf164, chromosome 9 open reading frame 164 , SEMAJ; semaphorin-4D; CD100; coll 4; FLJ39737; M sema G; A8; GR3; BB18; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; SEMAJ; coll-4; C9orf164; M-sema-G; FLJ33485; FLJ34282; FLJ46484; MGC169138; MGC169141
• Gene ID: 10507
• mRNA Refseq: NM_001142287
• Protein Refseq: NP_001135759
• MIM: 601866
• UniProt ID: Q92854
• Chromosome Location: 9q22-q31
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Sema4D in semaphorin signaling, organism-specific biosystem; Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem; Sema4D mediated inhibition of cell attachment and migration, organism-specific biosystem
• Function: protein binding; receptor activity; receptor binding; semaphorin receptor binding; transmembrane signaling receptor activity