SEMA3A
-
Official Full Name
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -
Overview
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimers disease. [provided by RefSeq, Jul 2008] -
Synonyms
SEMA3A;sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A;HH16;SemD;COLL1;SEMA1;SEMAD;SEMAL;coll-1;Hsema-I;SEMAIII;Hsema-III;semaphorin-3A;collapsin 1;semaphorin D;semaphorin L;semaphorin III
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- HEK293
- E.coli
- CHO
- Human Cell
- Mammalian Cell
- NS0
- Mammalian cells
- His&Fc
- GST
- His
- Fc
- Non
- His&T7
- His&Fc&Avi
- His&Flag
Involved Pathway
SEMA3A involved in several pathways and played different roles in them. We selected most pathways SEMA3A participated on our site, such as Axon guidance,CRMPs in Sema3A signaling,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | EFNA4,WDR83,DUSP9,DPYSL5A,STX1B,ITGB1B.1,JAK1,NRTN,MEF2AA,RASGEF1A |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | SEMA3AA,SEMA3AB,NRP1A |
| Sema3A PAK dependent Axon repulsion | NRP1A,SEMA3AB,SEMA3AA |
| Semaphorin interactions | PLXND1,SEMA3AB,CRMP1,CDK5R1B,DPYSL3,SEMA3AA,DPYSL2,NRP1A,DPYSL5B,DPYSL5A |
| Axon guidance | EPHA8,FRS2,PAK7,SCN8A,ITGB1,NRP1A,SEMA5A,SPTA1,EFNB2,CHL1 |
| CRMPs in Sema3A signaling | CRMP1,DPYSL3,SEMA3AA,CDK5,SEMA3AB,NRP1A,DPYSL2,CDK5R1B,DPYSL5B,DPYSL4 |
Protein Function
SEMA3A has several biochemical functions, for example, chemorepellent activity,neuropilin binding,semaphorin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA3A itself. We selected most functions SEMA3A had, and list some proteins which have the same functions with SEMA3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| neuropilin binding | SEMA3GB,SEMA3BL,SEMA3G,Sema3f,SEMA3AA,SEMA3FA,SEMA3E,SEMA3GA,SEMA4E,SEMA3H |
| semaphorin receptor binding | SEMA6E,SEMA3C,SEMA3AB,SEMA4E,SEMA6B,SEMA6D,SEMA4A,SEMA4BA,SEMA4C,SEMA3B |
| chemorepellent activity | NRG3,EFNA5,SEMA4C,SEMA3H,NRG1,SEMA6A,SEMA6B,SEMA3C,SEMA4B,SEMA6DL |
Interacting Protein
SEMA3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA3A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA3A.
Resources
Related Services
Related Products
References
- Venkova, K; Christov, A; et al. Semaphorin 3A Signaling Through Neuropilin-1 Is an Early Trigger for Distal Axonopathy in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 73:702-713(2014).
- Vadasz, Z; Haj, T; et al. A regulatory role for CD72 expression on B cells in systemic lupus erythematosus. SEMINARS IN ARTHRITIS AND RHEUMATISM 43:767-771(2014).
