PPBP
-
Official Full Name
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) -
Overview
CXCL7 which is a protein with a length of 70 amino acids, belongs to the family of chemotactic cytokines. The expression of CXCL7 is induced in human monocytes by treatment with bacterial endotoxins. It stimulates the release of elastase from neutrophils and shows some of the activities of IL8. CXCL7 interacts with the NAP-1 receptor and binds to one type of receptors that also binds IL8 and related factors. -
Synonyms
Ppbp;PPBP;pro-platelet basic protein (chemokine (C-X-C motif) ligand 7);platelet basic protein;neutrophil activating peptide-2;chemokine (C-X-C motif) ligand 7;Cxcl7;Nap-2
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- Pig
- Rabbit
- E.coli
- HEK293
- Wheat Germ
- Human
- Human Cell
- Human Cells
- CHO
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- GST
- Non
- Fc
- His
- His&GST
- Myc&DDK
Involved Pathway
PPBP involved in several pathways and played different roles in them. We selected most pathways PPBP participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CXCR3.1,IL11,IFNPHI1,IL26,CD27,IL-15RA,CRFB16,TNFSF13B,Ccl12,TGFB2 |
| Chemokine signaling pathway | CCL20,GNGT2,STAT1,ADRBK1,CXCR4,PTK2B,ARRB1,CCR9,BRAF,ROCK1 |
Protein Function
PPBP has several biochemical functions, for example, CXCR chemokine receptor binding,chemokine activity,glucose transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPBP itself. We selected most functions PPBP had, and list some proteins which have the same functions with PPBP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glucose transmembrane transporter activity | SLC2A5,SLC2A6,SLC2A3A,SLC2A11L,SLC2A15A,SLC2A11B,SLC2A15B,SLC2A1,SLC2A2,SLC2A8 |
| CXCR chemokine receptor binding | CXCL12,CXCL6,PF4V1,CXCL18B,CXCL2,CXCL12A,AMCF-II,CXCL1,CXCL20,ITCH |
| growth factor activity | HGF,GDF5,GDF10B,BMP7B,BMP8A,FGF8A,LEFTY2,IL8L2,FGF13,PROK1 |
| chemokine activity | CCL28,CCL20,CCL35.2,CXCL9,CXCL11,CCL14,IL-8,XCL1,CCL25,CCL22 |
Interacting Protein
PPBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPBP here. Most of them are supplied by our site. Hope this information will be useful for your research of PPBP.
EFNA1;NR4A1;RPS27;DMWD;PMAIP1;COX17;MAPK6;MOB3B;rarD;SCFD1;fadE;CELF1;QRSL1;STRN4;PLEKHJ1;NDUFB11;CMTM6;COPS7A;COPG1
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