KLRK1
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Official Full Name
Klrk1 killer cell lectin-like receptor subfamily K, member 1 -
Overview
NKG2D is a lectin-like type II transmembrane protein also known as CD314. It is expressed on NK cells, a subset of CD8+ T cells, gamma/delta T cells and NK1.1+ T cells, as well as in vitro induced LAK cells. NKG2D serves as a stimulatory immunoreceptor to activate NK cells via the non-covalently associated DAP10 or DAP12 adaptor. Several molecules have been identified as the ligands for NKG2D, including minor histocompatibility molecule, H60, UL16-binding protein-like transcript 1 (Mult1, and a family of retinoic acid early transcript 1 (Rae1) in mice, MHC class-I chain-related protein A (MICA), MICB, and UL16-binding proteins (ULBPs) in humans. present in both mice and humans. NKG2D ligands trigger cytokine (IFN-gamma, GM-CSF, TNF-alpha, MIP1beta and others) and granzyme release from NK cells. -
Synonyms
KLRK1;killer cell lectin-like receptor subfamily K, member 1;NKG2-D type II integral membrane protein;NK cell receptor D;natural killer cell group 2D;NKG2-D-activating NK receptor;Nkg2d;NKG2-D;D6H12S2489E
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Rat
- Mus musculus
- Macaca fascicularis
- Insect Cells
- Insect Cell
- Mammalian cells
- HEK293
- N-His
- E.coli
- Mammalian Cell
- CHO
- Baculovirus-Insect Cells
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- Fc
- lFc
- N-hFc-Flag
- His&T7
- Non
- Fc&Avi
- mFc
- His&Fc&Avi
- His&Fc
- GST
- N-His-Avi
Involved Pathway
KLRK1 involved in several pathways and played different roles in them. We selected most pathways KLRK1 participated on our site, such as Natural killer cell mediated cytotoxicity,Malaria, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLRK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Malaria | HBA1,COMP,TLR4,TLR9,THBS4,MYD88,IFNG,TLR2,LRP1,TNF |
| Natural killer cell mediated cytotoxicity | PIK3R5,MAP2K2,SH2D1B,PRKCA,PRF1,PIK3CB,TNFSF10,NFATC1,HLA-G,RAET1G |
Protein Function
KLRK1 has several biochemical functions, for example, carbohydrate binding,protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLRK1 itself. We selected most functions KLRK1 had, and list some proteins which have the same functions with KLRK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SETDB1,CLTA,PRSS2,IL7,RANBP2,DDIT4L,GCKR,RAB39B,ELF1,RPS16 |
| carbohydrate binding | LGALSL,LGALS3L,MAN2A2,LGALS2B,GALNT13,GALNT2,LPHN1,SBP,FCN1,LMAN1L |
| receptor activity | PVRL3,ROBO4,GFRA1A,PVRL3B,SIGLEC7,VMN1R54,CALCR,GRIN2BB,FOLR1,KIR2DL3 |
Interacting Protein
KLRK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLRK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLRK1.
MICA;ULBP3;RAET1G;HCST
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