Active Recombinant Human Killer Cell Lectin-Like Receptor Subfamily K, Member 1, Fc-tagged

• Cat.No.: KLRK1-5673H
• Product Overview: Recombinant Human KLRK1protein was expressed in Murine myeloma cell line with the Fc part of humanIgG1 Pro100-Lys330 (N-terminus) and Phe78-Val216 (C-terminus).

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Fc
• Protein Length: 78-216 a.a.
• Description: KLRK1 is a type IItransmembrane glycoprotein having an extracellular lectin-like domain. Thisdomain lacks the recognizable calcium-binding sites found in true C-typelectins and binds protein rather than carbohydrate ligands. Human KLRK1 isexpressed on CD8+ αβ T cells, γδ T cells, NK cells and NKT cells. In mousesystems KLRK1 also occurs on macrophages. Human ligands for KLRK1 includeMICA, MICB, and ULBP1, 2, and 3. Expression of KLRK1 ligands occurs inepithelial cells, tumor cells and under conditions of stress or infection.
• Form: Lyophilized from a0.2 μm filtered solution in PBS.
• N-terminalSequence: Met
• Molecular Weight: 43 kDa
• Activity: Measuredby its ability to bind its ligand, rhMICA/Fc Chimera in a functional ELISA.
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• SDS-PAGE: 50-55kDa, reducing conditions.
• Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 100μg/mL in sterile PBS
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.

Gene Information

• Gene Name: KLRK1 killer cell lectin-likereceptor subfamily K, member 1 [ Homo sapiens ]
• Official Symbol: KLRK1
• Synonyms: KLRK1; killer cell lectin-likereceptor subfamily K, member 1; KLR; CD314; NKG2D; NKG2-D; D12S2489E;FLJ17759; FLJ75772; NKG2-D type II integral membrane protein; NK cell receptorD; NKG2-D-activating NK receptor; Killer cell lectin-like receptor subfamilyK member 1; DNA segment on chromosome 12 (unique) 2489 expressed sequence;OTTHUMP00000239062; OTTHUMP00000239064; CD314 antigen
• Gene ID: 22914
• mRNA Refseq: NM_007360
• Protein Refseq: NP_031386
• MIM: 611817
• UniProt ID: P26718
• Chromosome Location: 12p13.2-p12.3
• Pathway: Adaptive ImmuneSystem; Immune System; Immunoregulatory interactions between a Lymphoid and anon-Lymphoid cell; Malaria; Natural killer cell mediated cytotoxicity