HLA-G
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- Overview
- Review / Q&A
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Official Full Name
major histocompatibility complex, class I, G -
Overview
HLA-G is a nonclassical MHC class I (MHC-Ib) molecule structurally related to MHC class Ia (HLA-A,B, C). There are seven isoforms of this molecule, including membrane bound HLA-G1, -G2, -G3 and -G4 and soluble HLA-G5, -G6, and -G7. HLA-G is primarily expr -
Synonyms
HLA-G;major histocompatibility complex, class I, G;HLA G histocompatibility antigen, class I, G;HLA class I histocompatibility antigen, alpha chain G;b2 microglobulin;HLA G antigen;HLA class I molecule;MHC class I antigen G;HLA-G histocompatibility antigen, class I, G;MHC-G
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- HEK293
- E.coli
- Wheat Germ
- Mammalian Cells
- Insect cells
- Yeast
- In Vitro Cell Free System
- Avi
- His
- B2M
- GST
- DDK
- Myc
- SUMO
- Non
- Fc
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-G-312H |
Recombinant Human HLA-G Protein, His-Avi-tagged
|
HEK293 | Human | Avi&His | It contains Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide. | |
| HLA-G-4305H |
Recombinant Human HLA-G protein, His-B2M-tagged
|
E.coli | Human | B2M&His | 25-308aa | |
| HLA-G-1241H | Recombinant Human HLA-G Protein | HEK293 | Human | His | 25-338 a.a. | |
| HLA-G-13828H | Recombinant Human HLA-G, GST-tagged | E.coli | Human | GST | 26-308a.a. | |
| HLA-G-27H | Recombinant Human HLA-G protein, GST-tagged | Wheat Germ | Human | GST | 1-338 a.a. | |
| HLA-G-001H | Active Recombinant Human HLA-G Protein, Myc/DDK-tagged | HEK293 | Human | DDK&Myc | ||
| HLA-G-033H | Recombinant Human HLA-G Protein, His-tagged | E.coli | Human | His | 26-308 aa | |
| HLA-G-39H | Recombinant Human HLA-G protein | E.coli | Human | His&SUMO | 25-338 a.a. | |
| HLA-G-501H |
Active Recombinant Human HLA-G protein, His-Avi-tagged
|
HEK293 | Human | Avi&His | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
|
| HLA-G-505HP |
Active Recombinant Human HLA-G complex Protein (tetramer), His-Avi-tagged, PE-Labeled
|
HEK293 | Human | Avi&His | Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide |
|
| HLA-G-26H | Recombinant Human HLA-G protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
|
|
| HLA-G-38H | Recombinant Human HLA-G protein | E.coli | Human | His | 25-338 a.a. |
|
| HLA-G-1077H | Recombinant Human HLA-G Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
|
|
| HLA-G-1718HFL | Recombinant Full Length Human HLA-G Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
|
| HLA-G-2243H | Recombinant Human HLA-G Protein, His-tagged | E.coli | Human | His | Gly25-Ile308 |
|
| HLA-G-2792HFL | Recombinant Full Length Human HLA-G protein, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
|
| HLA-G-3036H | Recombinant Human HLA-G protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 25-308aa |
|
| HLA-G-3075H | Recombinant Human HLA-G Protein (Met29-His117), N-GST tagged | E.coli | Human | GST | Met29-His117 |
|
| HLA-G-3322H | Recombinant Human HLA-G protein, His-tagged | Insect cells | Human | His | 25-319aa |
|
| HLA-G-502H | Recombinant Human HLA-G protein(Gly25-Thr305(C66S)), His-Avi-tagged | E.coli | Human | Avi&His | Gly25-Thr305(C66S) |
|
| HLA-G-503C | Recombinant Cynomolgus HLA-G protein, His-Avi-tagged | HEK293 | Cynomolgus | Avi&His | Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide |
|
| HLA-G-503CB | Recombinant Cynomolgus HLA-G protein, His-Avi-tagged, Biotinylated | HEK293 | Cynomolgus | Avi&His | Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide |
|
| HLA-G-503H | Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated | HEK293 | Human | Avi&His | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
|
| HLA-G-504H | Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated | HEK293 | Human | Avi&His | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
|
| HLA-G-505C | Recombinant Cynomolgus HLA-G Tetramer protein, His-Avi-tagged | HEK293 | Cynomolgus | Avi&His | Gly25-Thr305(HLA-G)&Ile21-Met119(B2M) |
|
| HLA-G-506R | Recombinant Rhesus macaque HLA-G protein, His-Avi-tagged | HEK293 | Rhesus macaque | Avi&His | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
|
| HLA-G-5426H | Recombinant Human HLA-G protein | Yeast | Human | His&SUMO | 25-338 a.a. |
|
| HLA-G-651HF | Recombinant Full Length Human HLA-G Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 338 amino acids |
|
Involved Pathway
HLA-G involved in several pathways and played different roles in them. We selected most pathways HLA-G participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | WNT9B,MRAS,ANAPC2,TNFRSF1A,TBPL2,WNT8A,TGFB2,RB1,FOSL1,HLA-DQA1 |
| Endocytosis | GIT2A,CHMP2BB,ARFGAP2,SNF8,IQSEC1,EPN1,IST1,TGFB2,VPS37C,ZFYVE20 |
| ne thyroid disease | CD80,HLA-DRB4,H2-Q10,IFNA6,IFNA5,Ifna15,HLA-DOA,IFNA7,TSHB,IFNA8 |
| Type I diabetes mellitus | HLA-DQA2,Fasl,HLA-DRA,PRF1,HLA-DOA,H2-AA,HLA-DOB,LTA,HLA-F,HLA-A |
| Viral carcinogenesis | GSN,RANBP1,HIST1H2BK,PRKACA,HIST1H4F,HLA-C,SND1,PKM2,HIST2H2BE,HNRNPK |
| Phagosome | BMA2,BMA1,TFR1A,CTSSB.2,TUBA2,THBS4B,CANX,ATPV0E2,TLR4BA,RAB7B |
| Graft-versus-host disease | H2-AA,KLRD1,HLA-A,IL1B,HLA-DQA2,HLA-B,GZMB,CD86,KLRC1,IL1A |
| Natural killer cell mediated cytotoxicity | FCER1G,Ifna11,IFNA2,PIK3CD,FCGR3A,GM-CSF,ULBP1,KLRC4-KLRK1,KIR2DS5,KLRC2 |
| Antigen processing and presentation | HSPA8,KIR2DL1,KIR2DS3,KIR2DS5,HLA-DMA,HSPA1B,HLA-E,HLA-DPA1,PSME1,HSPA6 |
Protein Function
HLA-G has several biochemical functions, for example, peptide antigen binding,protein homodimerization activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-G itself. We selected most functions HLA-G had, and list some proteins which have the same functions with HLA-G. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | MHC1ZFA,HLA-DRB4,MHC1ZE,TAPBP,MR1,MHC1UXA2,HLA-DRB1,H2-AA,HLA-DRA,CD209 |
| protein homodimerization activity | BNIP3,PEX7,EVLA,PRMT2,SLC11A1,UGT1A9,ENG,CACYBP,PDGFRA,VAPB |
| receptor binding | PGR,CD200,A2M,SLC9A3R1,CADM1B,ECH1,PVRL3B,TNFSF13B,FGF18A,PARK7 |
Interacting Protein
HLA-G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-G here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-G.
LILRB1;HLA-A
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References
- Han, MY; Jiang, YZ; et al. sHLA-G Involved in the Apoptosis of Decidual Natural Killer Cells Following Toxoplasma gondii Infection. INFLAMMATION 37:1718-1727(2014).
- Brugiere, O; Thabut, G; et al. Role of HLA-G as a Predictive Marker of Low Risk of Chronic Rejection in Lung Transplant Recipients: A Clinical Prospective Study. AMERICAN JOURNAL OF TRANSPLANTATION 15:461-471(2015).
