GHR
-
Official Full Name
growth hormone receptor -
Overview
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011] -
Synonyms
GHR;growth hormone receptor;GHBP;GH receptor;serum binding protein;somatotropin receptor;growth hormone binding protein
Recombinant Proteins
- Mouse
- Rat
- Rabbit
- Cynomolgus
- Chicken
- Human
- Rhesus macaque
- Bovine
- Ovine
- Pig
- Dog
- Oryctolagus cuniculus (Rabbit)
- Bos indicus (Zebu)
- Mus musculus
- Sus scrofa (Pig)
- Macaca mulatta
- HEK293
- E.coli
- Mammalian cells
- Mammalian Cell
- Mouse myeloma cell line
- Insect Cell
- Human Cell
- CHO
- Wheat Germ
- E.coli expression system
- His
- C-His & hFc
- Non
- Fc
- C-His&hFc
- His&SUMO
- His&T7
- His&Myc
- His&Fc
- N-His&C-Myc
- GST
- His&Fc&Avi
Involved Pathway
GHR involved in several pathways and played different roles in them. We selected most pathways GHR participated on our site, such as Cytokine-cytokine receptor interaction,Neuroactive ligand-receptor interaction,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GHR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TNFRSF13C,CCR3,CCL21B,IL11RA2,GM13304,IL17A,CCR10,TNFRSF10D,TSLP,IL29 |
| Jak-STAT signaling pathway | PIK3CD,SOCS2,CTF1,NT5C3,IL2RG,Il2,IL3RA,IL22RA1,IL6R,IL23 |
| Neuroactive ligand-receptor interaction | LPAR6,GABRG2,GABRE,NPY7R,CSH2,HCRTR1,CHRNA2,LHB,GALR1,AVPR1B |
| PIK-Akt signaling pathway | PKN1,COL6A4,FGF2,ITGB5,FGF16,IFNA14,FGF3,PCK1,FIGF,TEK |
Protein Function
GHR has several biochemical functions, for example, cytokine receptor activity,growth factor binding,peptide hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GHR itself. We selected most functions GHR had, and list some proteins which have the same functions with GHR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide hormone binding | GALR1,PTH1RA,GCGR,AGTR1B,GHRHR,AVPR1A,MC3R,HCRTR2,MC4R,RXFP2 |
| protein kinase binding | CDK5,PRKAB1,PIWIL1,TBC1D14,CALM2,ILK,PLK1,PGAM1,PFKFB2,TELO2 |
| cytokine receptor activity | Ifnlr1,LIFRA,CD74,F3B,IL28RA,IL31RA,CRFB17,IRX1,CSF3R,IL15RA |
| protein homodimerization activity | MCL1A,IL6R,TMEM173,CHEK2,ODC1,TIRAP,TESCA,BOKB,BCL2A1A,TERT |
| growth factor binding | FLT4,NRP2,RHBDF1,GHRHR,HTRA1B,IGFBP2B,OSMR,ERBB3,LTBP2,LTBP4 |
| protein binding | Fert2,PIWIL1,IRF7,TMEM106B,KLF12,BAG4,IL32,Itga10&Itgb1,KTI12,SPANXA1 |
| proline-rich region binding | FAM59A,TCERG1,CCND1,CSK,BAIAP2L1,BAIAP2,ABL1,NEDD4,CYLD,PRPF40A |
Interacting Protein
GHR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GHR here. Most of them are supplied by our site. Hope this information will be useful for your research of GHR.
PTPRB;PTPN2;PTPN1;PTPN3
Resources
Related Services
Related Products
References
- Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
- Beckwith, H; Yee, D; et al. INSULIN-LIKE GROWTH FACTORS, INSULIN, AND GROWTH HORMONE SIGNALING IN BREAST CANCER: IMPLICATIONS FOR TARGETED THERAPY. ENDOCRINE PRACTICE 20:1214-1221(2014).
