GH1
-
Official Full Name
growth hormone 1 -
Overview
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. -
Synonyms
gH;GH-N;GH1;GHN;Growth hormone 1;Growth hormone;Growth hormone, normal;Growth hormone, pituitary;HG1;hGH-N;IGHD1B;Pituitary growth hormone;RNGHGP;SOMA_HUMAN;Somatotropin
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Bovine
- Rhesus macaque
- Dog
- Rabbit
- Horse
- Pig
- Cattle
- E.coli
- Nicotiana Benthamiana
- Human
- Zebrafish
- Mammalian Cells
- Human Cells
- HEK293
- CHO
- Wheat Germ
- In Vitro Cell Free System
- Human Pituitary Gland
- His
- Non
- StrepII
- His&T7
- Myc&DDK
- His&Fc&Avi
- SUMO&His
- MBP&His
- His&Myc
- GST
- His&Avi
- His&Fc
Involved Pathway
GH1 involved in several pathways and played different roles in them. We selected most pathways GH1 participated on our site, such as Cytokine-cytokine receptor interaction,Neuroactive ligand-receptor interaction,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCR8L,KITLGB,TNFRSF8,CCL3L3,NGFRB,GDF5,FLT4,CXCL5,CSF2RB,CLCF1 |
| PIK-Akt signaling pathway | PTK2,EPO,PIK3R5,PPP2R5A,VTN,IGF1,PPP2R3A,GSK3B,PRL,RPS6KB1 |
| Neuroactive ligand-receptor interaction | GHSRA,ADORA2AB,CHRNA10,TACR3A,PTH1RB,GALR2,ADORA2AA,P2RX5,GABRG1,CHRNB3B |
| Jak-STAT signaling pathway | IFNA3,MCL1,AOX4,Gh,IL21R.1,CSF3R,CNTFR,PIAS4B,RAF1B,IL9R |
Protein Function
GH1 has several biochemical functions, for example, growth factor activity,growth hormone receptor binding,hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GH1 itself. We selected most functions GH1 had, and list some proteins which have the same functions with GH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth hormone receptor binding | Gh,SOCS2,JAK1,JAK2,TYK2 |
| growth factor activity | CTGF,PROK1,AMBN,RABEP1,BMP5,PRL2C3,GDF5,FGF24,VEGFC,VEGFAB |
| metal ion binding | ZNF558,PFKL,RPS27L,ATP8A1,Car9,C6AST1,EXOG,EME1,PHLPP2,ZNF483 |
| protein binding | CCNE1,USH1G,KCTD9,SMNDC1,PVRL2,SMN1,ADAMTSL5,EIF5A,SAV1,GSE1 |
| hormone activity | RLN3A,RLN3,CCK,C1QTNF9,PRL2A1,METRNL,ADM2A,SST,CALCA,GH2 |
| prolactin receptor binding | PRL4A1,PRL,HSD17B7 |
Interacting Protein
GH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GH1.
GHR;PRLR;5730104;PSMD12;PSMD3;DNAJB6;CSDE1;DNAJC8;GOT2;NPM1;ANXA2;APRT;HNRNPC;RHOC;LTA4H
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References
- Low, JGH; Lee, LS; et al. Safety and immunogenicity of a virus-like, particle pandemic influenza A (H1N1) 2009 vaccine: Results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers. VACCINE 32:5041-5048(2014).
- Kedzial, A; Tarka, A; et al. Placental growth hormone (PGH), pituitary growth hormone (GH1), insulin-like growth factor (IGF-I) and ghrelin in pregnant women's blood serum. GINEKOLOGIA POLSKA 84:620-623(2013).
