Active Recombinant Human GH1 (1-217aa)

• Cat.No.: GH1-241H
• Product Overview: Human GH1 (P01241, 1 a.a.-217 a.a.) full-length recombinant protein expressed in Escherichia coli.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: Somatotropin is a protein that in humans is encoded by the GH1 gene. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones that play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation, an arrangement thought to have evolved by a series of gene duplications.
• Sequence: MATGSRTSLL LAFGLLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLHQLA FDTYQEFEEA YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE LLRISLLLIQ SWLEPVQFLR SVFANSLVYG ASDSNVYDLL KDLEEGIQTL MGRLEDGSPR TGQIFKQTYS KFDTNSHNDD ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF
• Theoretical MW (kDa): 22
• Form: Lyophilized
• Preparation Method: Escherichia coli expression system
• Purity: > 95% by SDS-PAGE and HPLC
• Endotoxin Level: < 0.1 ng/ug (1 EU/ug)
• Activity: The ED50 was determined by the dose-dependent cell proliferation assay using the rat lymphoma, Nb2-11, and was found to be in the range of 0.1 ng/mL.
• Application: SDS-PAGE
• Storage Buffer: Lyophilized from 0.005 mM NaHCO3 solution pH 10
• Storage: Store at -20°C on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing.
• Unitprot ID: P01241
• Pathways: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Neuroactive ligand-receptor interaction

Gene Information

• Gene Name: GH1 growth hormone 1 [ Homo sapiens ]
• Official Symbol: GH1
• Synonyms: GH; GH-N; GHN; hGH-N; Growth hormone; Pituitary growth hormone; growth hormone 1; GH1; IGHD1B; Somatotropin; hGH
• Gene ID: 2688
• mRNA Refseq: NM_000515
• Protein Refseq: NP_000506
• MIM: 139250
• Chromosome Location: 17q24.2
• Function: growth factor activity; growth hormone activity; growth hormone receptor binding; prolactin receptor binding; protein binding