Fgfr3

  • Official Full Name

    fibroblast growth factor receptor 3

  • Overview

    This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]

  • Synonyms

    FGFR3;fibroblast growth factor receptor 3;ACH;CEK2;JTK4;CD333;HSFGFR3EX;FGFR-3;tyrosine kinase JTK4;hydroxyaryl-protein kinase;fibroblast growth factor receptor 3 variant 4

Recombinant Proteins

  • Mouse
  • Monkey
  • Human
  • Cynomolgus
  • Chicken
  • Zebrafish
  • HEK293
  • Mammalian cells
  • Human Cell
  • Sf9 Insect Cell
  • Insect Cell
  • E.coli
  • Human
  • Mammalian Cell
  • HEK293E
  • Human Cells
  • HEK293T
  • Wheat Germ
  • In Vitro Cell Free System
  • Yeast
  • Mamanlian cells
  • E.coli expression system
  • His&Fc
  • His
  • Fc
  • His&Avi
  • Non
  • GST
  • Flag
  • His&T7
  • his
  • Myc&DDK
  • His&Flag
  • N-StrepII and C-His
  • His&Fc&Avi
  • His&B2M
Cat.# Product name Source (Host) Species Tag Protein Length Price
Fgfr3-836MAF488 Active Recombinant Mouse Fgfr3 Protein, His/Fc-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His&Fc 595
Fgfr3-836MAF555 Active Recombinant Mouse Fgfr3 Protein, His/Fc-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His&Fc 595
Fgfr3-836MAF647 Active Recombinant Mouse Fgfr3 Protein, His/Fc-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His&Fc 595
Fgfr3-836MF Active Recombinant Mouse Fgfr3 Protein, His/Fc-tagged, FITC conjugated HEK293 Mouse His&Fc 595
Fgfr3-624M Active Recombinant Mouse Fgfr3 protein(Met1-Tyr367), His-tagged HEK293 Mouse His Met1-Tyr367
FGFR3-1224CAF488 Recombinant Cynomolgus FGFR3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Monkey His 364
FGFR3-1224CAF555 Recombinant Cynomolgus FGFR3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Monkey His 364
FGFR3-1224CAF647 Recombinant Cynomolgus FGFR3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Monkey His 364
FGFR3-1224CF Recombinant Cynomolgus FGFR3 Protein, His-tagged, FITC conjugated HEK293 Monkey His 364
FGFR3-204CAF488 Recombinant Monkey FGFR3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Monkey Fc Met1-Gly375， 594
FGFR3-204CAF555 Recombinant Monkey FGFR3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Monkey Fc Met1-Gly375， 594
FGFR3-204CAF647 Recombinant Monkey FGFR3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Monkey Fc Met1-Gly375， 594
FGFR3-204CF Recombinant Monkey FGFR3 Protein, Fc-tagged, FITC conjugated HEK293 Monkey Fc Met1-Gly375， 594
FGFR3-6072HB Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated HEK293 Human His&Avi Glu23-Gly377
Fgfr3-624MAF488 Recombinant Mouse Fgfr3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His 358
Fgfr3-624MAF555 Recombinant Mouse Fgfr3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His 358
Fgfr3-624MAF647 Recombinant Mouse Fgfr3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His 358
Fgfr3-624MF Recombinant Mouse Fgfr3 Protein, His-tagged, FITC conjugated HEK293 Mouse His 358
FGFR3-751HAF488 Recombinant Human FGFR3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 591
FGFR3-751HAF555 Recombinant Human FGFR3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 591
FGFR3-751HAF647 Recombinant Human FGFR3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 591
FGFR3-751HF Recombinant Human FGFR3 Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 591
FGFR3-752HAF488 Recombinant Human FGFR3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 364
FGFR3-752HAF555 Recombinant Human FGFR3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 364
FGFR3-752HAF647 Recombinant Human FGFR3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Human His 364
FGFR3-752HF Recombinant Human FGFR3 Protein, His-tagged, FITC conjugated HEK293 Human His 364
FGFR3-779HAF488 Recombinant Human FGFR3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 593
FGFR3-779HAF555 Recombinant Human FGFR3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 593
FGFR3-779HAF647 Recombinant Human FGFR3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 593
FGFR3-779HF Recombinant Human FGFR3 Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 593
FGFR3-780HAF488 Recombinant Human FGFR3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 366
FGFR3-780HAF555 Recombinant Human FGFR3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 366
FGFR3-780HAF647 Recombinant Human FGFR3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Human His 366
FGFR3-780HF Recombinant Human FGFR3 Protein, His-tagged, FITC conjugated HEK293 Human His 366
Fgfr3-536M Active Recombinant Mouse Fibroblast Growth Factor Receptor 3, Fc-tagged Mammalian cells Mouse Fc 33-367 a.a.
FGFR3-609H Active Recombinant Human FGFR3, His-tagged, Biotinylated Human Cell Human His 23-375 a.a.
FGFR3-610H Active Recombinant Human FGFR3, Fc-tagged, Biotinylated Human Cell Human Fc 23-375 a.a.
FGFR3-611H Active Recombinant Human FGFR3, Fc-tagged Human Cell Human Fc 23-375 a.a.
FGFR3-612H Active Recombinant Human FGFR3, His-tagged Human Cell Human His 23-375 a.a.
FGFR3-700H Active Recombinant Human FGFR3, Fc Chimera Mammalian cells Human Fc
FGFR3-8320H Active Recombinant Human FGFR3 Mammalian cells Human Non
Fgfr3-836M Active Recombinant Mouse Fgfr3 Protein, His & Fc-tagged HEK293 Mouse His&Fc 1-367 a.a.
FGFR3-87H Active Recombinant Human FGFR3, GST-tagged Sf9 Insect Cell Human GST 397-end a.a.
FGFR3-88H Active Recombinant Human FGFR3, GST-tagged Sf9 Insect Cell Human GST 397-end a.a.
FGFR3-89H Active Recombinant Human FGFR3, GST-tagged Sf9 Insect Cell Human GST 397-end a.a.
FGFR3-03H Recombinant Human Fibroblast Growth Factor Receptor 3, Fc-tagged Insect Cell Human Fc
FGFR3-119H Recombinant Human FGFR3 Protein, DDK-tagged Insect Cell Human Flag
FGFR3-1224C Recombinant Cynomolgus FGFR3 Protein, His-tagged HEK293 Cynomolgus His 1-375 a.a.
Fgfr3-1739M Recombinant Mouse Fibroblast Growth Factor Receptor 3 Mammalian cells Mouse Non
FGFR3-1811H Recombinant Human FGFR3 protein, His & T7-tagged E.coli Human His&T7 Val166~Gly375
FGFR3-204C Active Recombinant Cynomolgus FGFR3 protein, hFc-tagged HEK293 Cynomolgus Fc Met1-Gly375
FGFR3-227H Recombinant Human PLXNA1 Protein, His-tagged Sf9 Insect Cell Human GST 43-300 a.a.
FGFR3-28835TH Recombinant Human FGFR3 Human Non 397-end a.a.
FGFR3-28836TH Recombinant Human FGFR3, Fc-tagged Human Fc
FGFR3-315H Recombinant Human FGFR3, GST-tagged, Active Sf9 Insect Cell Human GST 397-end a.a.
FGFR3-46H Recombinant Human FGFR3 protein, Flag-tagged, Biotinylated Insect Cell Human Flag 436-806 a.a.
FGFR3-5003H Recombinant Human Fibroblast Growth Factor Receptor 3 Human Human Non
FGFR3-5419H Recombinant Human Fibroblast Growth Factor Receptor 3, His-tagged Insect Cell Human his 399-806 a.a.
FGFR3-59H Recombinant Human FGFR3 (V555M), GST-tagged Sf9 Insect Cell Human GST 397-end a.a.
FGFR3-7058C Recombinant Chicken FGFR3 Mammalian Cell Chicken His
Fgfr3-706M Recombinant Mouse Fgfr3 protein, His/Fc-tagged HEK293 Mouse His&Fc Met 1-Tyr 367
FGFR3-751H Active Recombinant Human FGFR3 protein, Fc-tagged HEK293 Human Fc Glu23-Gly375
FGFR3-752H Recombinant Human FGFR3 Protein, His-tagged, HPLC-verified HEK293 Human His 1-375 a.a.
FGFR3-779H Active Recombinant Human FGFR3 protein, Fc-tagged HEK293 Human Fc Glu23-Gly377
FGFR3-780H Recombinant Human FGFR3 Protein, His-tagged HEK293 Human His 1-377 a.a.
FGFR3-78H Recombinant Human FGFR3, MYC/DDK-tagged HEK293 Human Myc&DDK
FGFR3-79H Recombinant Human FGFR3, DDK/His-tagged HEK293 Human His&Flag
FGFR3-80H Recombinant Human FGFR3, DDK/His-tagged HEK293 Human His&Flag
FGFR3-81H Recombinant Human FGFR3, DDK/His-tagged HEK293 Human His&Flag
FGFR3-9146Z Recombinant Zebrafish FGFR3 Mammalian Cell Zebrafish His
FGFR3-001CCL Recombinant Cynomolgus FGFR3 cell lysate Human Cell Cynomolgus Non
FGFR3-2596MCL Recombinant Mouse FGFR3 cell lysate Human Cell Mouse Non
FGFR3-001H Recombinant Human FGFR3 Protein, Fc-His-tagged HEK293E Human His&Fc 1-372
Fgfr3-021M Recombinant Mouse fibroblast growth factor receptor 3 Protein, His&StrepII tagged HEK293 Mouse N-StrepII and C-His 21-369aa
FGFR3-093H Recombinant Human FGFR3 protein, His-Avi-tagged HEK293 Human His&Avi Asp127-Gly377
FGFR3-093HB Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated HEK293 Human His&Avi Asp127-Gly375
Fgfr3-10554M Recombinant Mouse Fgfr3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
Fgfr3-10554M-B Recombinant Mouse Fgfr3 Protein Pre-coupled Magnetic Beads HEK293 Mouse
FGFR3-151H Recombinant Human FGFR3 Protein, His-tagged Human Cells Human His
FGFR3-187H Recombinant Human FGFR3 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
FGFR3-187H-B Recombinant Human FGFR3 Protein Pre-coupled Magnetic Beads HEK293 Human
FGFR3-207H Recombinant Human FGFR3 Protein, hIgG-His-tagged Insect Cell Human His&Fc 23-375aa
FGFR3-2668H Active Recombinant Human FGFR3 protein, hFc&His-tagged HEK293 Human His&Fc Glu23-Gly375
FGFR3-2916H Recombinant Human FGFR3 protein, His-tagged E.coli Human His 23-375aa
FGFR3-2917H Recombinant Human FGFR3 protein, His-B2M-tagged E.coli Human His&B2M 397-806aa
Fgfr3-3003M Recombinant Mouse Fgfr3 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
FGFR3-4114H Recombinant Human FGFR3 protein(Met1-Gly377), His-tagged HEK293 Human His Met1-Gly377
FGFR3-4115H Recombinant Human FGFR3 Protein (Met1-Gly375), C-His tagged Mammalian cells Human His Met1-Gly375
FGFR3-4134H Recombinant Human FGFR3 Protein Wheat Germ Human Non
FGFR3-4135H Recombinant Human FGFR3 Protein, Fc/His-tagged HEK293E Human His&Fc 1-372 a.a.
FGFR3-4136H Active Recombinant Human FGFR3 Protein, GST-tagged Insect Cell Human GST 436-806 a.a.
FGFR3-4137H Recombinant Human FGFR3 Protein, GST-tagged Wheat Germ Human GST
FGFR3-4893HF Recombinant Full Length Human FGFR3 Protein In Vitro Cell Free System Human Full L. 315 amino acids
FGFR3-5405H Recombinant Human FGFR3 protein, His-tagged Yeast Human His 23-375aa
FGFR3-5406H Recombinant Human FGFR3 protein, His-tagged Yeast Human His 397-806aa
FGFR3-607H Recombinant Human FGFR3 protein, His-Avi-tagged HEK293 Human His&Avi Glu23-Gly375(IIIc)
FGFR3-607HB Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated HEK293 Human His&Avi Glu23-Gly375
FGFR3-608H Recombinant Human FGFR3 protein, His-Avi-tagged HEK293 Human His&Avi Glu23-Gly377(IIIb)
FGFR3-6094HFL Recombinant Full Length Human FGFR3, Flag-tagged Mamanlian cells Human Flag Full L.
FGFR3-612HB Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated HEK293 Human His&Avi Asp127-Gly377
FGFR3-613H Recombinant Human FGFR3 protein, His-Avi-tagged HEK293 Human His&Avi Asp127-Gly375
FGFR3-93H Recombinant Human FGFR3 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Human His&Fc Glu23-Gly375
RFL12486GF Recombinant Full Length Chicken Fibroblast Growth Factor Receptor 3(Fgfr3) Protein, His-Tagged E.coli expression system Chicken His Full L. Full Length of Mature Protein (20-806)

    Involved Pathway

    Fgfr3 involved in several pathways and played different roles in them. We selected most pathways Fgfr3 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgfr3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway SHC2,GNG10,PDGFA,CALM4,PDGFRB,GRIN2B,MET,ANGPT2,FGF3,FGF10
    Endocytosis GRK1B,CHMP5B,SNX1A,TRAF6,PARD6B,ARF3A,CYTH3,GRK4,PIP5K1AB,BIN1B
    Bladder cancer MDM2,BRAF,E2F2,RB1,UPK3A,ERBB2,TRP53,RASSF1,THBS1,MMP9
    MAPK signaling pathway HSPA1L,TGFB1A,PRKACA,MRAS,ACVR1C,RPS6KA3,TGFBR1,TGFBR2,TAOK3,GADD45BB
    PIK-Akt signaling pathway RPS6KB2,PGF,LAMA4,FGF3,PKN2,Gh,NGFR,GNG3,RXRA,BCL2
    Signaling pathways regulating pluripotency of stem cells AXIN1,MAPK3,WNT5A,PIK3R2,PIK3CB,TCF3,GSK3B,OTX1,SMAD1,BMPR1A
    Regulation of Actin Cytoskeleton PPP1CB,MYL2,ARHGEF7B,SSH1,DIAP3,ITGA2B,ITGB6,PIK3R2,PIP5K1AA,MYL12.2
    MicroRNAs in cancer BMI1,CDC25A,SPRY2,DDIT4,ZEB2,CD44,UBE2I,PRKCG,NOTCH2,FOXP1
    Pathways in cancer RB1,IL6,CCND1,HDAC1,LAMB2,FZD6,NFKBIA,FGF4,BCL2,MSH2

    Protein Function

    Fgfr3 has several biochemical functions, for example, ATP binding,fibroblast growth factor binding,fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgfr3 itself. We selected most functions Fgfr3 had, and list some proteins which have the same functions with Fgfr3. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PVRL2,STAU2,FZD3,TNFRSF6B,PRPS1,SEPT12,CD164,RABL2,SYNGR1,CNBP
    fibroblast growth factor binding CXCL13,PTPRZ1,FGFR1A,KLB,S100A13,FIBPA,RPS2,CEP57,FGFR2,TGFBR3
    ATP binding UBE2B,PSMC2,ATP6AP1,UBA7,GARS,CENPE,ABCA1,ACSS3,DCK,MAPK14
    protein tyrosine kinase activity LYN,JAK3,CLK2,TNK2B,DYRK2,BLK,PTK2BB,FER,MAP3K9,JAK1
    fibroblast growth factor-activated receptor activity FGFRL1,FGFR4,FGFR1A,FGFR1,FGFR2,FGFR1B

    Interacting Protein

    Fgfr3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgfr3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgfr3.

    FGF1;HSP90AB1;saicar;PKM;CTGF;abl-tide;HSPG2;CDC37;NDUFS6;HBZ;CHGB;KRT8;SLC25A6;HNRNPL;ATF3;CTSK

    Fgfr3 Related Signal Pathway

    Resources

    Gene Families

    Cytokines

    Research Area

    Cancer Drug Targets
    FGF Family
    Other CD Antigen
    Receptor Tyrosine Kinases (RTKs)
    FGF Receptor
    Head and Neck Cancer Biomarkers
    Oncoprotein-Growth Factor Receptors

    References

    • Correa, D; Somoza, RA; et al. Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. OSTEOARTHRITIS AND CARTILAGE 23:443-453(2015).
    • Kim, B; Wang, S; et al. Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. ONCOGENE 34:1083-1093(2015).

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